所有图片(1)
别名:
4-（2-氨基乙氧基）-N2,N6-双[4-（2-氨基乙氧基）-2-喹啉基]-2,6-吡啶二甲酰胺 三氟乙酸盐, RR82 三氟乙酸盐
经验公式（希尔记法）:
C31H32N8O5 · xC2HF3O2
CAS号:
分子量:
596.64 (free base basis)
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
推荐产品
质量水平
检测方案
≥98% (HPLC)
形式
powder
储存条件
protect from light
颜色
white to beige
溶解性
H2O: 15 mg/mL, clear
储存温度
−20°C
SMILES字符串
OC(C(F)(F)F)=O.O=C(NC1=CC(OCCN)=C(C=CC=C2)C2=N1)C3=CC(OCCN)=CC(C(NC4=NC(C=CC=C5)=C5C(OCCN)=C4)=O)=N3
InChI
1S/C31H32N8O5.C2HF3O2/c32-9-12-42-19-15-24(30(40)38-28-17-26(43-13-10-33)20-5-1-3-7-22(20)36-28)35-25(16-19)31(41)39-29-18-27(44-14-11-34)21-6-2-4-8-23(21)37-29;3-2(4,5)1(6)7/h1-8,15-18H,9-14,32-34H2,(H,36,38,40)(H,37,39,41);(H,6,7)
InChI key
SLFYRKZWSPFGQZ-UHFFFAOYSA-N
应用
Pyridostatin 三氟乙酸盐已被用作 G-四链体（G4）稳定剂，来研究 RNA G4 和配体分子之间的相互作用。
生化/生理作用
Pyridostatin 是一种高选择性 G-四链体相互作用分子。它通过诱导依赖于 DNA 损伤的复制/转录来抑制人癌细胞的生长。
Pyridostatin 稳定 G-四链体，靶向原癌基因 SRC 和端粒 G-四链体，诱导 DNA 损伤和细胞周期停滞。
其他说明
光敏感
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Chandran A
Advancing Development of Synthetic Gene Regulators: With the Power of High-Throughput Sequencing in Chemical Biology. (2017)
RNA Helicase DDX1 Converts RNA G-Quadruplex Structures into R-Loops to Promote IgH Class Switch Recombination.
de Almeida C R, et al.
Molecular Cell (2018)
Investigation of higher-order RNA G-quadruplex structures in vitro and in living cells by 19 F NMR spectroscopy.
Bao H L and Yan X
Nature Protocols, 13(4), 652-652 (2018)
RTEL1 suppresses G-quadruplex-associated R-loops at difficult-to-replicate loci in the human genome.
Wei Wu et al.
Nature structural & molecular biology, 27(5), 424-437 (2020-05-14)
Oncogene activation during tumorigenesis generates DNA replication stress, a known driver of genome rearrangements. In response to replication stress, certain loci, such as common fragile sites and telomeres, remain under-replicated during interphase and subsequently complete locus duplication in mitosis in
Diana C Odermatt et al.
PLoS genetics, 16(6), e1008740-e1008740 (2020-06-17)
FANCJ/BRIP1 is an iron-sulfur (FeS) cluster-binding DNA helicase involved in DNA inter-strand cross-link (ICL) repair and G-quadruplex (G4) metabolism. Mutations in FANCJ are associated with Fanconi anemia and an increased risk for developing breast and ovarian cancer. Several cancer-associated mutations
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