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质量水平
方案
≥98% (HPLC)
表单
powder
储存条件
desiccated
颜色
white to beige
溶解性
H2O: 15 mg/mL, clear
储存温度
2-8°C
SMILES字符串
N1C[C@@H](CC1)N(CCc3c(cccc3)OC)C(=O)c2ccc(cc2)CN(CC)CC
InChI
1S/C25H35N3O2/c1-4-27(5-2)19-20-10-12-22(13-11-20)25(29)28(23-14-16-26-18-23)17-15-21-8-6-7-9-24(21)30-3/h6-13,23,26H,4-5,14-19H2,1-3H3/t23-/m1/s1
InChI key
XKPJTOHUPQWSOJ-HSZRJFAPSA-N
应用
PF-429242二盐酸盐已被用作固醇调节元件结合蛋白（SREBP）的抑制剂。
生化/生理作用
PF-429242是S1P（细胞前蛋白转化酶固醇调节元件结合蛋白（SREBP）位点1蛋白酶）的一种有效抑制剂。
PF-429242是S1P（细胞前蛋白转化酶固醇调节元件结合蛋白（SREBP）位点1蛋白酶）的一种有效抑制剂，可降低小鼠肝脏SREBP靶基因的表达水平并降低胆固醇和脂肪酸的合成速率。 PF-429242是一种有效的抗病毒剂，可对抗培养的细胞中的原型鼻咽病毒淋巴细胞性脉络膜脑膜炎病毒（LCMV）和LASV。 PF-429242可有效地阻止LCMV和LASV对GPC的影响。PF-429242可能能够靶向CCHFV起作用。
警示用语：
Warning
危险分类
Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Siqingaowa et al.
Biochemical and biophysical research communications, 488(1), 136-140 (2017-05-10)
Sterol regulatory element-binding protein1 (SREBP1) is a key regulatory factor that controls lipid homeostasis. Overactivation of SREBP1 and elevated lipid biogenesis are considered the major characteristics in malignancies of prostate cancer, endometrial cancer, and glioblastoma. However, the impact of SREBP1
Fatostatin inhibits cancer cell proliferation by affecting mitotic microtubule spindle assembly and cell division.
Gholkar A A, et al.
The Journal of Biological Chemistry, 291(33), 17001-17008 (2016)
Ruofan Wang et al.
Cell, 184(1), 106-119 (2020-12-18)
The Coronaviridae are a family of viruses that cause disease in humans ranging from mild respiratory infection to potentially lethal acute respiratory distress syndrome. Finding host factors common to multiple coronaviruses could facilitate the development of therapies to combat current
Jessica D Rosarda et al.
ACS chemical biology, 16(12), 2852-2863 (2021-11-20)
The extracellular accumulation of glutamate is a pathologic hallmark of numerous neurodegenerative diseases including ischemic stroke and Alzheimer's disease. At high extracellular concentrations, glutamate causes neuronal damage by promoting oxidative stress, which can lead to cellular death. This has led
Tian Du et al.
Breast cancer research : BCR, 20(1), 106-106 (2018-09-06)
Invasive lobular breast carcinoma (ILC) is a histological subtype of breast cancer that is characterized by loss of E-cadherin and high expression of estrogen receptor alpha (ERα). In many cases, ILC is effectively treated with adjuvant aromatase inhibitors (AIs); however
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