推荐产品
质量水平
方案
≥95% (HPLC)
表单
oil
储存条件
desiccated
颜色
colorless to yellow
储存温度
2-8°C
SMILES字符串
Cl.Cl.CCC(C)C(N)C(=O)NCCN1CCOCC1
InChI
1S/C12H25N3O2.2ClH/c1-3-10(2)11(13)12(16)14-4-5-15-6-8-17-9-7-15;;/h10-11H,3-9,13H2,1-2H3,(H,14,16);2*1H
InChI key
LLIHJRRZJDEKLB-UHFFFAOYSA-N
应用
LM11A-31 dihydrochloride has been used to study the effect of p75 neurotrophin receptor (p75 NTR) blockade, by non-peptide LM11A-31 ligand, on PC12 cell viability.
生化/生理作用
LM11A-31 is a non-peptide ligand of the p75 neurotrophin receptor (p75NTR). LM11A-31 blocks pro-NGF induced cell death in neuronal cultures, and protects neuronal cells from the the cytotoxic effects of cisplatin or methotrexate. Oral administration of LM11A-31 promotes the survival of oligodendrocytes and myelinated axons in a mouse spinal cord injury model and improves function in both weight-bearing and non-weight bearing tests.
LM11A-31 is a p75 neurotrophin receptor (p75NTR) ligand.
警示用语：
Warning
危险分类
Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Different responses of PC12 cells to different pro-nerve growth factor protein variants
Soligo M, et al.
Neurochemistry International, 129, 104498-104498 (2019)
Marzia Soligo et al.
Neurochemistry international, 129, 104498-104498 (2019-07-07)
The present work aimed to explore the innovative hypothesis that different transcript/protein variants of a pro-neurotrophin may generate different biological outcomes in a cellular system. Nerve growth factor (NGF) is important in the development and progression of neurodegenerative and cancer
Valentina Pallottini et al.
Cells, 9(10) (2020-10-08)
Despite its undisputable role in the homeostatic regulation of the nervous system, the nerve growth factor (NGF) also governs the relevant cellular processes in other tissues and organs. In this study, we aimed at assessing the expression and the putative
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