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Merck
CN
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主要文件

SML0649

Sigma-Aldrich

脱羟基 LY-411575

≥98% (HPLC)

别名:

γ-Secretase inhibitor XX, (S,S)-2-[2-(3,5-Difluorophenyl)acetylamino]-N-(5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)propionamide, DBZ, Dibenzazepine, GSI-XX, N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-benzeneacetamide, YO-01027

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About This Item

经验公式（希尔记法）:
C26H23F2N3O3
CAS号:
209984-56-5
分子量:
463.48
UNSPSC代码:
12352200
NACRES:
NA.77

质量水平

100

方案

≥98% (HPLC)

表单

powder

旋光性

[α]/D -128.0 to -154.0°-0.25 in methanol

颜色

white to beige

溶解性

DMSO: 15 mg/mL, clear

储存温度

−20°C

SMILES字符串

Fc1cc(cc(c1)CC(=O)N[C@@H](C)C(=O)N[C@H]2c3c(cccc3)c4c(cccc4)N(C2=O)C)F

InChI

1S/C26H23F2N3O3/c1-15(29-23(32)13-16-11-17(27)14-18(28)12-16)25(33)30-24-21-9-4-3-7-19(21)20-8-5-6-10-22(20)31(2)26(24)34/h3-12,14-15,24H,13H2,1-2H3,(H,29,32)(H,30,33)/t15-,24-/m0/s1

InChI key

QSHGISMANBKLQL-OWJWWREXSA-N

应用

Deshydroxy LY-411575 has been used in dibenzazepine (DBZ) treatment and chemical treatment.

生化/生理作用

Deshydroxy LY-411575 is a cell-permeable γ-secretase inhibitor and inhibtor of Notch processing.
Deshydroxy LY-411575 is a cell-permeable γ-secretase inhibitor and inhibtor of Notch processing. Deshydroxy LY-411575 significantly lowers both brain and plasma Aβ40 levels by ~72% in Tg2576 mutant APP transgenic mouse model and potently blocks Notch processing, with an IC50 of 1.7 nM in SupT1 cells.
LY411575 prevents SPP (signal peptide peptidase) dependent cleavage of HCV (hepatitis C virus) core protein.

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302,H317

危险分类

Acute Tox. 4 Oral - Skin Sens. 1A

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000384753
0000384756
0000384756
0000384753
0000240303

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Qiuping He et al.
Experimental hematology, 51, 1-6 (2017-05-01)
During development, hematopoietic stem cells (HSCs) undergo a rapid expansion in the fetal liver (FL) after their emergence in the aorta-gonad-mesonephros (AGM) region. We recently reported that the endolysosomal trafficking factor BLOS2, encoded by the Bloc1s2 gene, regulates HSC/hematopoietic progenitor
Inhibitory effect of presenilin inhibitor LY411575 on maturation of hepatitis C virus core protein, production of the viral particle and expression of host proteins involved in pathogenicity.
Otoguro T, et al.
Microbiology and Immunology, 60(11), 740-753 (2016)
Yan Li et al.
Development (Cambridge, England), 149(10) (2022-05-04)
The earliest hematopoietic stem and progenitor cells (HSPCs) are generated from the ventral wall of the dorsal aorta, through endothelial-to-hematopoietic transition during vertebrate embryogenesis. Notch signaling is crucial for HSPC generation across vertebrates; however, the precise control of Notch during
G protein-coupled receptor 183 facilitates endothelial-to-hematopoietic transition via Notch1 inhibition.
Zhang P, et al.
Cell Research, 25(10), 1093-1093 (2015)
Pooja Hor et al.
iScience, 23(5), 101083-101083 (2020-05-08)
Expansion of pulmonary neuroendocrine cells (PNECs) is a pathological feature of many human lung diseases. Human PNECs are inherently difficult to study due to their rarity (<1% of total lung cells) and a lack of established protocols for their isolation.
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