SML0632
Fialuridine
≥98% (HPLC), powder, nucleoside analog
别名:
1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodo-2,4(1H,3H)-Pyrimidinedione, FIAU
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关于此项目
经验公式（希尔记法）:
C9H10FIN2O5
化学文摘社编号:
分子量:
372.09
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
Fialuridine, ≥98% (HPLC)
SMILES string
F[C@H]1[C@H](O)[C@@H](CO)O[C@H]1N2C(NC(C(I)=C2)=O)=O
InChI key
IPVFGAYTKQKGBM-BYPJNBLXSA-N
InChI
1S/C9H10FIN2O5/c10-5-6(15)4(2-14)18-8(5)13-1-3(11)7(16)12-9(13)17/h1,4-6,8,14-15H,2H2,(H,12,16,17)/t4-,5+,6-,8-/m1/s1
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 5 mg/mL, clear (warmed)
storage temp.
−20°C
Quality Level
General description
非阿尿苷（1-（2-脱氧-2-氟-β——5-碘尿嘧啶或FIAU） 是一种抗病毒剂。它是一种基于胸苷的核苷类似物。
Application
非阿尿苷被用于无性系筛选。
Biochem/physiol Actions
非阿尿苷是一种核苷类似物抗病毒剂。
非阿尿苷是一种核苷类似物抗病毒剂。该化合物表现出显著的线粒体毒性。
非阿尿苷（1-（2-脱氧-2-氟-β-d-阿拉伯糖呋喃）-5-碘尿嘧啶或 FIAU）及其代谢产物阻断多个相邻类似物掺入位点的 DNA 聚合酶，减少 mtDNA（线粒体 DNA）并导致肝祖细胞中的线粒体结构缺陷。其视为抗乙型肝炎病毒 (HBV) 感染的高效药物。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Joo Ho Tai et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 49(1), 94-102 (2007-12-14)
We are combining nuclear medicine with molecular biology to establish a sensitive, quantitative, and tomographic method with which to detect gene expression in pancreatic islet cells in vivo. Dual-isotope SPECT can be used to image multiple molecular events simultaneously, and
Stephanie L Davis et al.
PloS one, 4(7), e6297-e6297 (2009-07-17)
Bacteria can be selectively imaged in experimentally-infected animals using exogenously administered 1-(2'deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-[(125)I]-iodouracil ([(125)I]-FIAU), a nucleoside analog substrate for bacterial thymidine kinase (TK). Our goal was to use this reporter and develop non-invasive methods to detect and localize Mycobacterium tuberculosis. We
P Honkoop et al.
Drug safety, 17(1), 1-7 (1997-07-01)
Fialuridine is an antiviral agent with potent activity against hepatitis B virus replication in vitro and in vivo. In a phase II study, 7 of 15 patients experienced severe toxicity due to the drug after 9 to 13 weeks of
Kristin L Peterson et al.
Nuclear medicine and biology, 40(5), 638-642 (2013-04-02)
Currently available infectious disease imaging techniques cannot differentiate between infection and sterile inflammation or between different types of infections. Recently, radiolabeled FIAU was found to be a substrate for the thymidine kinase (TK) enzyme of multiple pathogenic bacteria, leading to
De-Xue Fu et al.
Nature medicine, 14(10), 1118-1122 (2008-09-09)
We investigated the possibility of using a pharmacologic agent to modulate viral gene expression to target radiotherapy to tumor tissue. In a mouse xenograft model, we had previously shown targeting of [(125)I]2'-fluoro-2'-deoxy-beta-D-5-iodouracil-arabinofuranoside ([(125)I]FIAU) to tumors engineered to express the Epstein-Barr
商品
Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
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