SML0621
WZB117
≥98% (HPLC)
别名:
3-氟-1,2-亚苯基双（3-羟基苯甲酸酯）, 3-羟基苯甲酸 1,1′-（3-氟-1,2-亚苯基）酯
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关于此项目
经验公式（希尔记法）:
C20H13FO6
化学文摘社编号:
分子量:
368.31
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
WZB-117, ≥98% (HPLC)
Quality Level
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
DMSO: 20 mg/mL, clear
storage temp.
2-8°C
SMILES string
O=C(C1=CC=CC(O)=C1)OC2=C(F)C=CC=C2OC(C3=CC(O)=CC=C3)=O
InChI
1S/C20H13FO6/c21-16-8-3-9-17(26-19(24)12-4-1-6-14(22)10-12)18(16)27-20(25)13-5-2-7-15(23)11-13/h1-11,22-23H
InChI key
FRSWCCBXIHFKKY-UHFFFAOYSA-N
Application
WZB-117 已被用于研究其在肿瘤干细胞中的肿瘤起始能力。也用于研究葡萄糖拮抗剂对 2-NBDG（2-（N-（7-硝基苯并-2-氧杂-1,3-二唑-4-基）氨基）-2-脱氧葡萄糖）摄取的影响。
Biochem/physiol Actions
WZB-117 是一种不可逆抑制剂。在癌细胞中，WZB-117 通过在任何葡萄糖浓度下刺激细胞凋亡来防止细胞生长。它靶向肿瘤干细胞的自我更新和肿瘤起始能力。
WBZ 117 是 H1299 肺癌和其他癌细胞中基础葡萄糖转运的抑制剂。
WBZ 117 是一种基础葡萄糖转运抑制剂。
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Modulation of Glucose Takeup by Glucose Transport on the Isolated OHCs.
Cheng X T, et al.
Neural Plast., 2018, 7-7 (2018)
Masaki Tsuchiya et al.
Communications biology, 7(1), 459-459 (2024-04-17)
Cellular glucose uptake is a key feature reflecting metabolic demand of cells in physiopathological conditions. Fluorophore-conjugated sugar derivatives are widely used for monitoring glucose transporter (GLUT) activity at the single-cell level, but have limitations in in vivo applications. Here, we
Stroma-derived HGF drives metabolic adaptation of colorectal cancer to angiogenesis inhibitors.
Mira A, et al.
Oncotarget, 8(24), 38193-38193 (2017)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SML0621-25MG | 04061832633992 |
| SML0621-5MG | 04061837101182 |