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Merck
CN
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文件

安全信息

SML0610

Sigma-Aldrich

氯化两面针碱

≥97% (HPLC)

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别名:
2,3-Dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridinium chloride, NSC 146397
经验公式（希尔记法）:
C21H18NO4 · Cl
CAS号:
13063-04-2
分子量:
383.82
MDL编号:
MFCD01659688
UNSPSC代码:
12352200
NACRES:
NA.77

检测方案

≥97% (HPLC)

形式

powder

颜色

white to beige

溶解性

DMSO: 1 mg/mL, clear (warmed)

运输

wet ice

储存温度

−20°C

SMILES字符串

C[N+]1=CC2=CC(OC)=C(OC)C=C2C3=CC=C4C=C5C(OCO5)=CC4=C31.[Cl-]

InChI

1S/C21H18NO4.ClH/c1-22-10-13-7-17(23-2)18(24-3)8-15(13)14-5-4-12-6-19-20(26-11-25-19)9-16(12)21(14)22;/h4-10H,11H2,1-3H3;1H/q+1;/p-1

InChI key

QLDAACVSUMUMOR-UHFFFAOYSA-M

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生化/生理作用

Nitidine chloride is a natural product with anti-cancer activity. Its mechanism of action likely involves several pathways. Nitidine chloride has been found to inhibit topoisomerase I and topoisomerase II, induce cell apoptosis by activation of the caspase-dependent pathway, suppress c-Src/FAK associated signaling pathways and suppress Janus kinase 2/STAT3 signaling and the expression of STAT3-dependent target genes, including cyclin D1, Bcl-xL, and VEGF. Nitidine chloride has also been found to have anti-malaria activity.

特点和优势

This compound is featured on the Caspases, Fak and JAKs pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险声明

H300

预防措施声明

P301 + P310 + P330

危险分类

Acute Tox. 2 Oral

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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Zhiqing Fang et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 60, 246-251 (2013-08-06)
Nitidine Chloride (NC) has been shown to have anti-cancer effects on various tumors. However, whether NC could exert anti-metastasis activity in renal cancer cells and the underlying mechanisms have not been elucidated. In this work, our data demonstrated the anti-metastasis
Mathieu Blanchot et al.
Organic letters, 13(6), 1486-1489 (2011-02-26)
The use of aryl triflates as reaction partners in a palladium-catalyzed domino direct arylation/N-arylation provides a great advantage due to the availability of starting materials. Furthermore, it allows expedient access to biologically interesting benzo[c]phenanthridine alkaloids.
S Zhang et al.
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 24(9), 649-650 (2002-01-22)
To determine the nitidine in different parts of Zanthoxylum nitidum (Roxb.) DC. HPLC method was used. The column was HYPERSIL BDS C18. The mobile phase was 0.02 mol/L monobasic potassium phosphate: acetonitrile (66:34). The detective wavelength was 328 nm. The
Huagang Liu et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 34(11), 1406-1409 (2009-09-24)
A high performance liquid chromatography (HPLC) method was developed to determine the concentration of nitidine chloride in plasma and successfully applied to study pharmacokinetics after i.v. administration in rabbits. Twelve rabbits, randomized into 2 groups , were given i.v. at
Shu Yang et al.
Fitoterapia, 81(8), 1026-1032 (2010-07-14)
The inducing abilities of two alkaloids, Sanguinarine (San) and Nitidine (Nit), to fold human telomeric DNA d[5'-TTGGG(TTAGGG)(3)A-3'] (H24A) into G-quadruplex structures has been investigated by using CD and (1)H NMR spectroscopy. It is found that, under salt-deficiency condition, San could
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