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Merck
CN
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文件

安全信息

SML0604

Sigma-Aldrich

SB-399885 hydrochloride

≥98% (HPLC)

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别名:
N-(3,5-Dichloro-2-methoxyphenyl)-4-methoxy-3-(1-piperazinyl)-benzenesulfonamide hydrochloride
经验公式(希尔记法):
C18H21Cl2N3O4S · HCl
分子量:
482.81
UNSPSC代码:
12352200
NACRES:
NA.77

质量水平

检测方案

≥98% (HPLC)

形式

powder

储存条件

desiccated

颜色

white to beige

溶解性

H2O: 15 mg/mL, clear

储存温度

room temp

InChI

1S/C18H21Cl2N3O4S/c1-26-17-4-3-13(11-16(17)23-7-5-21-6-8-23)28(24,25)22-15-10-12(19)9-14(20)18(15)27-2/h3-4,9-11,21-22H,5-8H2,1-2H3

InChI key

ATKZKAYWARYLBW-UHFFFAOYSA-N

生化/生理作用

SB-399885 is a potent, selective, and orally active 5-HT6 receptor antagonist with greater than 200 fold selectivity over other 5-HT receptors. SB-399885 is brain penetrant and displays antidepressant and anxiolytic activity in rodent models.

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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Ao Li et al.
CNS neuroscience & therapeutics, 27(8), 941-950 (2021-05-12)
General anesthesia has been widely applied in surgical or nonsurgical medical procedures, but the mechanism behind remains elusive. Because of shared neural circuits of sleep and anesthesia, whether serotonergic system, which is highly implicated in modulation of sleep and wakefulness

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