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Merck
CN

SML0601

BPTES

≥95% (HPLC), powder, glutaminase GLS1 (KGA) inhibitor

别名:

双-2-(5-苯基乙酰胺基-1,3,4-噻二唑-2-基)乙基硫醚

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关于此项目

经验公式（希尔记法）:
C24H24N6O2S3
化学文摘社编号:
314045-39-1
分子量:
524.68
UNSPSC Code:
12352200
PubChem Substance ID:
329825569
NACRES:
NA.77
MDL number:
MFCD01079848

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产品名称

BPTES, ≥95% (HPLC)

SMILES string

O=C(CC1=CC=CC=C1)NC2=NN=C(S2)CCSCCC3=NN=C(NC(CC4=CC=CC=C4)=O)S3

InChI

1S/C24H24N6O2S3/c31-19(15-17-7-3-1-4-8-17)25-23-29-27-21(34-23)11-13-33-14-12-22-28-30-24(35-22)26-20(32)16-18-9-5-2-6-10-18/h1-10H,11-16H2,(H,25,29,31)(H,26,30,32)

InChI key

MDJIPXYRSZHCFS-UHFFFAOYSA-N

assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

Quality Level

100

相关类别

Application

双-2-(5-苯基乙酰胺基-1,3,4-噻二唑-2-基)乙基硫醚（BPTES）已被用作谷氨酰胺酶抑制剂。

Biochem/physiol Actions

BPTES是谷氨酰胺酶GLS1的选择性抑制剂。
BPTES是谷氨酰胺酶GLS1（KGA）的选择性抑制剂，GLS1存在于肾和脑中，由myc正向调节，在许多肿瘤和肿瘤细胞系中高度表达。谷氨酰胺酶可将谷氨酰胺转化为谷氨酸，谷氨酸是脑中重要的兴奋性神经递质，可进一步氧化成α-酮戊二酸（供给三羧酸（TCA）循环）和谷胱甘肽，谷胱甘肽对控制活性氧（ROS）水平很重要，对癌细胞生长尤为重要。BPTES可减缓胶质瘤细胞的生长。BPTES是一种非竞争性抑制剂，Ki为3 μmM。
牛痘病毒（VACV）需要谷氨酰胺代谢才能实现最佳复制。双-2-(5-苯基乙酰胺基-1,3,4-噻二唑-2-基)乙基硫醚（BPTES）抑制谷氨酰胺分解可能有望治疗痘病毒感染。

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000248344
0000406336
0000248344
0000406336
0000484780

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