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质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 15 mg/mL, clear
储存温度
−20°C
SMILES字符串
N1([C@@H](c6c(cc(c(c6)OC)OC)CC1)Cc2ccc(cc2)Oc3c(ccc(c3)C[C@H]4N(CCc5c4cc(c(c5)OC)O)C)O)C
InChI
1S/C37H42N2O6/c1-38-15-13-26-20-36(43-4)37(44-5)22-29(26)30(38)16-23-6-9-27(10-7-23)45-35-18-24(8-11-32(35)40)17-31-28-21-33(41)34(42-3)19-25(28)12-14-39(31)2/h6-11,18-22,30-31,40-41H,12-17H2,1-5H3/t30-,31-/m1/s1
InChI key
BURJAQFYNVMZDV-FIRIVFDPSA-N
生化/生理作用
Daurisoline alkaloid isolated from the rhizomes of Menispermum dauricum that exhibit varies pharmacological activities including antiplatelet aggregation, anti-inflammatory, neuron-protective properties, and antiarrhythmic effect. It appears that antiarrhythmic effect of daurisoline is maintained through blockade of hERG channels.
Daurisoline is antiarrythmic, anti-inflammatory, neuron-protective; and blocks hERG channels.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
J Liu et al.
Yao xue xue bao = Acta pharmaceutica Sinica, 33(3), 165-170 (2002-04-10)
In this study, the protective effects of (-)-R.R-daurisoline and its three optical isomers on ischemic injury in cultured PC12 cells induced by treating cells with NaCN in glucose-free medium were investigated. Cell viability was measured using MTT assay. The results
X Pan et al.
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 21(9), 456-458 (2003-02-07)
The alkaloids of rhizoma of Menispermum dauricum DC growing in Xianning have been subjected to isolation and identification. The results showed that its two major constituents, which are only next of dauricine in content, are dauricinoline and daurinoline, instead of
Qiang-Ni Liu et al.
The American journal of Chinese medicine, 38(1), 37-49 (2010-02-04)
Our previous studies have shown that daurisoline (DS) exerted antiarrhythmic effects on various experimental arrhythmias. In this study, the effects of DS on early afterdepolarizations (EADs) and its possible mechanisms have been investigated. Cardiac hypertrophy was induced in rabbits by
J Liu et al.
Yao xue xue bao = Acta pharmaceutica Sinica, 33(3), 171-174 (2002-04-10)
The neuroprotective effects of (-)-S.R-daurisoline on glutamate-induced neurotoxicity were studied in rat primary cortical cultures. The inhibitory effects of (-)-S.R-daurisoline on glutamate-elicited free intracellular Ca2+ increase were also studied in freshly dissociated single brain cells isolated from new born rat
Z X Wang et al.
Yao xue xue bao = Acta pharmaceutica Sinica, 29(9), 647-651 (1994-01-01)
Standard microelectrode technique was used to study the effect of daurisoline (DS) on delayed afterdepolarization (DAD) and triggered activity (TA) in guinea pig ventricular trabeculae. DS (50 mumol.L-1) abolished TA induced by ouabain or caffeine, inhibited isoprenaline-induced TA, decreased incidence
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