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Merck
CN
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主要文件

SML0593

Sigma-Aldrich

CGP52432

≥98% (HPLC)

别名:

[3-[[(3,4-二氯苯基)甲基]氨基]丙基](二乙氧基甲基)次膦酸

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About This Item

经验公式(希尔记法):
C15H24Cl2NO4P
分子量:
384.24
UNSPSC代码:
12352200
NACRES:
NA.77

质量水平

方案

≥98% (HPLC)

表单

powder

储存条件

desiccated

颜色

white to beige

溶解性

H2O: 1 mg/mL, clear (warmed)

储存温度

2-8°C

SMILES字符串

[P](=O)(O)(C(OCC)OCC)CCCNCc1cc(c(cc1)Cl)Cl

InChI

1S/C15H24Cl2NO4P/c1-3-21-15(22-4-2)23(19,20)9-5-8-18-11-12-6-7-13(16)14(17)10-12/h6-7,10,15,18H,3-5,8-9,11H2,1-2H3,(H,19,20)

InChI key

GJZVQXWEIYRHBE-UHFFFAOYSA-N

应用

CGP52432已用作γ-氨基丁酸B(GABAB)拮抗剂:
  • 研究其对小鼠癫痫持续状态(SE)发作刺激的影响
  • 用于小鼠神经元的电压钳记录
  • 研究其对豚鼠海马体中GABAB受体介导神经传递的影响

生化/生理作用

CGP52432可抑制海马体中的甘氨酸溢流。
CGP52432是一种非常强效的GABAB受体拮抗剂。(IC50 = 85 nM)。

特点和优势

《受体分类和信号转导》手册的 GABAB受体页有该化合物的介绍。想要浏览手册的其他页面, 请单击此处

其他说明

注意:不要冻存。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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分析证书(COA)

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Cristina Romei et al.
Pharmacological research, 61(6), 547-552 (2010-02-09)
GABA(B) receptors mediate inhibition of neurotransmitter exocytosis from nerve endings. Unexpectedly, the well known GABA(B) receptor antagonist CGP35348 and, in part, the compound CGP52432, are now found to inhibit on their own the K(+)-evoked exocytosis of glycine when added at
Kazuo Kitamura et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(30), 10847-10858 (2011-07-29)
Cerebellar Purkinje cells have one of the most elaborate dendritic trees in the mammalian CNS, receiving excitatory synaptic input from a single climbing fiber (CF) and from ∼200,000 parallel fibers. The dendritic Ca(2+) signals triggered by activation of these inputs
A E Matukhno et al.
Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova, 62(3), 372-382 (2012-08-16)
By means of local microapplication of GABA, picrotoxin and CGP 52432, different roles of GABAA and GABAB receptors in the geneses of primary and secondary components of evoked potentials in the somatosensory barrel cortex of rats were shown. The authors
Chunguang Zhang et al.
Endocrinology, 150(5), 2388-2394 (2009-01-24)
Gamma-aminobutyric acid (GABA) is one of the most important neurotransmitters that regulate the excitability of GnRH neurons. Numerous studies have shown that GABA activates Cl(-) currents in GnRH neurons, and these effects are antagonized by GABA(A) receptor antagonists. The GABA(B)
Shuhei Kobuchi et al.
European journal of pharmacology, 623(1-3), 113-118 (2009-09-22)
Enhanced renal sympathetic nerve activity during ischemic period and the renal venous norepinephrine overflow after reperfusion play important roles in the development of ischemic acute kidney injury. We investigated the effect of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter mainly in

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