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Dear Customer:

The current international situation is complex and volatile, and uncertain tariff policies may potentially impact our product prices. Given these uncertainties, we value your understanding regarding order-related matters.

If you decide to place an order during this period, we reserve the right to adjust the price based on the evolving situation. We understand that market changes may cause inconvenience. We will negotiate with you if there’s a significant price fluctuation due to tariff policy changes before the order’s actual delivery, and in such cases we may adjust or cancel the order as necessary.

Merck
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主要文件

SML0583

Sigma-Aldrich

铁抑制剂-1

≥95% (HPLC), powder, non-apoptotic cell death inhibitor

别名:

3-氨基-4-环己基氨基苯甲酸乙酯;

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5 MG
CN¥923.58
25 MG
CN¥3,911.63

CN¥923.58


国内现货,预计发货时间April 25, 2025详情


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5 MG
CN¥923.58
25 MG
CN¥3,911.63

About This Item

经验公式(希尔记法):
C15H22N2O2
分子量:
262.35
UNSPSC代码:
12352200
NACRES:
NA.77

CN¥923.58


国内现货,预计发货时间April 25, 2025详情


获取大包装报价

产品名称

铁抑制剂-1, ≥95% (HPLC)

质量水平

方案

≥95% (HPLC)

表单

powder

颜色

, faint purple to brown

溶解性

DMSO: 10 mg/mL, clear

储存温度

2-8°C

SMILES字符串

N(C2CCCCC2)c1c(cc(cc1)C(=O)OCC)N

InChI

1S/C15H22N2O2/c1-2-19-15(18)11-8-9-14(13(16)10-11)17-12-6-4-3-5-7-12/h8-10,12,17H,2-7,16H2,1H3

InChI key

UJHBVMHOBZBWMX-UHFFFAOYSA-N

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此商品
F8927SML1390SML1925
Fexaramine ≥98% (HPLC)

SML1390

Fexaramine

form

powder

form

solid

form

powder

form

powder

assay

≥95% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥95% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: soluble >20 mg/mL, H2O: insoluble

solubility

DMSO: 10 mg/mL, clear

solubility

H2O: 10 mg/mL, clear

color

, faint purple to brown

color

white

color

white to beige

color

white to beige

应用

已经确定了铁抑制剂-1在细胞死亡上的抑制效果。[1][2]

生化/生理作用

铁抑制剂-1是一种活性自由基捕获抗氧化剂,能够捕获过氧自由基,可用作铁死亡的潜在抑制剂。铁死亡被认为是调节性坏死,和细胞凋亡和自吞噬不同。[3]铁抑制剂-1能够保护人们免于亨廷顿病,还能在细胞模型中防止谷氨酸诱导的神经毒性。[4]
铁抑制剂-1是一种高效的非凋亡的,erastin诱导铁死亡细胞死亡抑制剂。
铁抑制剂-1是一种高效的非凋亡的,erastin诱导铁死亡细胞死亡抑制剂。铁抑制剂-1能够防止癌症细胞中铁死亡细胞死亡和器官型大鼠脑切片中谷氨酸诱导毒性。铁抑制剂-1控制脂溶解ROS。

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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    Salinomycin kills cancer stem cells by sequestering iron in lysosomes.
    Mai T T, et al.
    Nature Chemistry, 9(10), 1025-1025 (2017)
    On the mechanism of cytoprotection by ferrostatin-1 and liproxstatin-1 and the role of lipid peroxidation in ferroptotic cell death.
    Zilka O, et al.
    ACS central science, 3(3), 232-243 (2017)
    The neuroprotective role of ferrostatin-1 under rotenone-induced oxidative stress in dopaminergic neuroblastoma cells.
    Kabiraj P, et al.
    The Protein Journal, 34(5), 349-358 (2015)
    Yimeng Xia et al.
    Frontiers in molecular neuroscience, 11, 486-486 (2019-01-29)
    The underlying mechanisms of isoflurane neurotoxicity in the developing brain remain unclear. Ferroptosis is a recently characterized form of programmed cell death distinct from apoptosis or autophagy, characterized by iron-dependent reactive oxygen species (ROS) generation secondary to failure of glutathione-dependent
    Rachel P L van Swelm et al.
    Cell death & disease, 9(5), 550-550 (2018-05-12)
    Hemoglobinuria is associated with kidney injury in various hemolytic pathologies. Currently, there is no treatment available and its pathophysiology is not completely understood. Here we studied the potential detrimental effects of hemoglobin (Hb) exposure to the distal nephron (DN). Involvement

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