SML0569
RO-3306
≥98% (HPLC), powder, CDK1 inhibitor
别名:
(5Z)-5-喹啉-6-基甲亚基-2-[(噻吩-2-基甲基)-氨基]-噻唑-4-酮, 5-(6-喹啉基甲亚基)-2-[(2-噻吩基甲基)氨基]-4(5H)-噻唑酮
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选择尺寸
关于此项目
经验公式（希尔记法）:
C18H13N3OS2
化学文摘社编号:
分子量:
351.45
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
产品名称
RO-3306, ≥98% (HPLC)
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
off-white to brown
溶解性
DMSO: 5 mg/mL, clear
储存温度
2-8°C
SMILES字符串
O=C1N=C(NCC2=CC=CS2)S/C1=C\C3=CC4=C(C=C3)N=CC=C4
InChI
1S/C18H13N3OS2/c22-17-16(24-18(21-17)20-11-14-4-2-8-23-14)10-12-5-6-15-13(9-12)3-1-7-19-15/h1-10H,11H2,(H,20,21,22)/b16-10-
InChI key
XOLMRFUGOINFDQ-YBEGLDIGSA-N
应用
RO-3306已可用于：
- 研究CA4介导的细胞毒性在有丝分裂阻滞中的重要性
- 在细胞周期同步化中进行蛋白质组学研究
- 作为CDK1抑制剂，防止进入早期有丝分裂
生化/生理作用
CDK1（细胞周期蛋白依赖性激酶1）被认为是细胞分裂的“主要开关”，它能够维持细胞的有丝分裂状态。
RO-3306是一种选择性ATP竞争性CDK1抑制剂。
RO-3306是一种选择性ATP竞争性CDK1抑制剂。 它能够抑制CDK1/cyclin B1的活性，Ki值为35 nM，它对CDK1/cyclin B1的选择性是CDK2/cyclin E的近10倍，是CDK4/cyclin D的50倍以上。RO-3306已可用于使细胞周期阻滞在G2/M期。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Tamara B Garcia et al.
Leukemia research, 64, 30-33 (2017-11-28)
Inhibition of WEE1 is emerging as a promising chemosensitization strategy in many cancers including acute leukemia. Our lab and others have demonstrated that a small-molecule inhibitor of WEE1, AZD1775, sensitizes acute leukemia cells to cytarabine; however, a mechanism of combinatorial
Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1.
Vassilev L T, et al.
Proceedings of the National Academy of Sciences of the USA, 103(28), 10660-10665 (2006)
Visualization of human karyopherin beta-1/importin beta-1 interactions with protein partners in mitotic cells by co-immunoprecipitation and proximity ligation assays.
Francesco L, et al.
Scientific Reports, 8(1), 1850-1850 (2018)
Alina Bluhm et al.
Nucleic acids research, 47(4), 1896-1907 (2019-01-11)
Telomeres are nucleoprotein structures at the ends of linear chromosomes and present an essential feature for genome integrity. Vertebrate telomeres usually consist of hexameric TTAGGG repeats, however, in cells that use the alternative lengthening of telomeres (ALT) mechanism, variant repeat
BRCA2 suppresses replication stress-induced mitotic and G1 abnormalities through homologous recombination.
Feng W and Jasin M
Nature Communications, 8(1), 525-525 (2017)
商品
Review properties, activators and inhibitors, and available products for researching cyclin-dependent kinases (CDKs).
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