跳转至内容
Merck
CN

SML0536

依法韦伦

≥98% (HPLC), nonnucleoside reverse transcriptase inhibitor (NNRTI), powder

别名:

依法韦伦, (4S)-6-氯-4-（2-环丙基乙炔基）-1,4-二氢-4-（三氟甲基）-2H-3,1-苯并恶嗪-2-酮

登录 查看组织和合同定价。

选择尺寸

关于此项目

经验公式（希尔记法）:
C14H9ClF3NO2
化学文摘社编号:
154598-52-4
分子量:
315.67
UNSPSC Code:
12352200
PubChem Substance ID:
329825539
NACRES:
NA.77
MDL number:
MFCD05662344

主要文件

查看所有文档
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助

产品名称

依法韦伦, ≥98% (HPLC)

Quality Level

100

SMILES string

ClC1=CC=C2C([C@@](C#CC3CC3)(C(F)(F)F)OC(N2)=O)=C1

InChI

1S/C14H9ClF3NO2/c15-9-3-4-11-10(7-9)13(14(16,17)18,21-12(20)19-11)6-5-8-1-2-8/h3-4,7-8H,1-2H2,(H,19,20)/t13-/m0/s1

InChI key

XPOQHMRABVBWPR-ZDUSSCGKSA-N

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D -90 to -100°, c = 1 in methanol

color

white to beige

solubility

DMSO: 15 mg/mL, clear

storage temp.

−20°C

正在寻找类似产品? 访问 产品对比指南

相关类别

Application

依法韦仑已用于：
  • 评估其抗猪内源性逆转录病毒（PERV）活性
  • 细胞毒性检测
  • 通过结合时间密度泛函理论（TD-DFT）和光谱计算的方法，研究依法韦仑的溶质-溶剂效应

Biochem/physiol Actions

依法韦仑是一种非核苷类逆转录酶抑制剂（NNRTI）。它是一种抗HIV药物，常用于AIDs治疗的联合疗法。它是用于治疗人类免疫缺陷病毒（HIV）1型的高效抗逆转录病毒疗法（HAART）的一部分。
依法韦仑是一种非核苷类逆转录酶抑制剂（NNRTI）；抗逆转录病毒。

Features and Benefits

这种化合物是 ADME 毒性研究的特色产品。点击此处发现更多特色 ADME 毒性产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

General description

具有Sustiva™商品名的依法韦仑是一种含有苯和恶嗪-2-酮发色团的多环芳烃。

Legal Information

Sustiva is a trademark of E. I. du Pont de Nemours and Company

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 1B

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000471382
0000471382
0000340755
0000340755
0000235199

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

L B Avery et al.
Antimicrobial agents and chemotherapy, 57(3), 1409-1414 (2013-01-09)
Efavirenz (EFV) is one of the most commonly prescribed antiretroviral drugs (ARVs) for the treatment of HIV. Highly protein-bound drugs, like EFV, have limited central nervous system (CNS) penetration when measured using total drug concentration gradients between blood plasma (BP)
A combined TD-DFT and spectroscopic investigation of the solute?solvent interactions of efavirenz.
Jordaan M A, et al.
Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy, 157, 204-210 (2016)
Rochelle P Walensky et al.
Annals of internal medicine, 158(2), 84-92 (2013-01-16)
U.S. HIV treatment guidelines recommend branded once-daily, 1-pill efavirenz-emtricitabine-tenofovir as first-line antiretroviral therapy (ART). With the anticipated approval of generic efavirenz in the United States, a once-daily, 3-pill alternative (generic efavirenz, generic lamivudine, and tenofovir) will decrease cost but may
Lawrence S U Lee et al.
Annals of the Academy of Medicine, Singapore, 41(12), 559-562 (2013-01-11)
Efavirenz is an inducer of drug metabolism enzymes. We studied the effect of efavirenz and ritonavir-boosted darunavir on serum unconjugated and conjugated bilirubin, as probes for UGT1A1 and bile transporters. Healthy volunteers were enrolled in a clinical trial. There were
"Efavirenz Inhibits the Human Ether-A-Go-Go Related Current (hERG) and Induces QT Interval Prolongation in CYP2B6* 6* 6 Allele Carriers.
Abdelhady A M, et al.
Journal of Cardiovascular Electrophysiology, 27(10), 1206-1213 (2016)
查看所有相关文献

商品

Bioactive Molecules for Immunology Research

Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.

Discover Bioactive Small Molecules for ADME/Tox

Discover Bioactive Small Molecules for ADME/Tox

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系客户支持