质量水平
检测方案
≥97% (HPLC)
形式
powder
颜色
white to beige
溶解性
DMSO: 5 mg/mL, clear
运输
wet ice
储存温度
−20°C
SMILES字符串
C[C@H](NC(=O)[C@@H](O)c1cc(F)cc(F)c1)C(=O)N[C@@H]2C(=O)N(C)c3ccccc3-c4ccccc24
InChI
1S/C26H23F2N3O4/c1-14(29-25(34)23(32)15-11-16(27)13-17(28)12-15)24(33)30-22-20-9-4-3-7-18(20)19-8-5-6-10-21(19)31(2)26(22)35/h3-14,22-23,32H,1-2H3,(H,29,34)(H,30,33)/t14-,22-,23-/m0/s1
InChI key
ULSSJYNJIZWPSB-CVRXJBIPSA-N
应用
LY-411575已被用作有效的γ-分泌酶抑制剂和Notch抑制剂。
生化/生理作用
LY-411575是一种有效的细胞渗透性和选择性γ-分泌酶抑制剂,可在急性或慢性治疗后降低Aβ/42,并阻断Notch活化。研究(癌细胞)已显示用LSN-411575治疗可通过抑制HES1表达和ERK磷酸化,阻滞KrasG12V驱动的NSCLC。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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