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Merck
CN

SML0506

Sigma-Aldrich

LY-411575

≥97% (HPLC)

别名:

LSN-411575, LY 411575, N2-[(2S)-2-(3,5-二氟苯基)-2-羟基乙酰]-N1-[(7S)-5-甲基-6-氧代-6,7-二氢-5H-二苯并[b,d]氮杂-7-基]-L-丙氨酰胺

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About This Item

经验公式(希尔记法):
C26H23F2N3O4
分子量:
479.48
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77

质量水平

检测方案

≥97% (HPLC)

形式

powder

颜色

white to beige

溶解性

DMSO: 5 mg/mL, clear

运输

wet ice

储存温度

−20°C

SMILES字符串

C[C@H](NC(=O)[C@@H](O)c1cc(F)cc(F)c1)C(=O)N[C@@H]2C(=O)N(C)c3ccccc3-c4ccccc24

InChI

1S/C26H23F2N3O4/c1-14(29-25(34)23(32)15-11-16(27)13-17(28)12-15)24(33)30-22-20-9-4-3-7-18(20)19-8-5-6-10-21(19)31(2)26(22)35/h3-14,22-23,32H,1-2H3,(H,29,34)(H,30,33)/t14-,22-,23-/m0/s1

InChI key

ULSSJYNJIZWPSB-CVRXJBIPSA-N

应用

LY-411575已被用作有效的γ-分泌酶抑制剂和Notch抑制剂。

生化/生理作用

LY-411575是一种有效的细胞渗透性和选择性γ-分泌酶抑制剂,可在急性或慢性治疗后降低Aβ/42,并阻断Notch活化。研究(癌细胞)已显示用LSN-411575治疗可通过抑制HES1表达和ERK磷酸化,阻滞KrasG12V驱动的NSCLC。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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K Pandya et al.
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The Journal of Biological Chemistry, 290(28), 17415-17438 (2015)

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