所有图片(1)
别名:
[2,3-二氯-4-(2-噻吩基羰基)苯氧基]-乙酸, 替尼酸, 烯酸
经验公式（希尔记法）:
C13H8Cl2O4S
CAS号:
分子量:
331.17
EC 号:
MDL编号:
UNSPSC代码:
12161501
PubChem化学物质编号:
NACRES:
NA.77
推荐产品
质量水平
检测方案
≥98% (HPLC)
形式
powder
颜色
white to beige
溶解性
DMSO: 5 mg/mL (clear solution)
运输
wet ice
储存温度
−20°C
SMILES字符串
OC(=O)COc1ccc(c(Cl)c1Cl)C(=O)c2cccs2
InChI
1S/C13H8Cl2O4S/c14-11-7(13(18)9-2-1-5-20-9)3-4-8(12(11)15)19-6-10(16)17/h1-5H,6H2,(H,16,17)
InChI key
AGHANLSBXUWXTB-UHFFFAOYSA-N
生化/生理作用
替尼酸（Ticrynafen）是一种P450抑制剂，是CYP2C9和CYP2C10的一种特异性自杀底物。它曾经被用作具有降尿酸（增加尿酸排泄）活性的利尿药，但由于其肝毒性而被市场淘汰。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Mahendra Ramesh Shiradkar et al.
Bioorganic & medicinal chemistry, 15(19), 6397-6406 (2007-07-24)
Based on the earlier results of our in-house database and compound library, a series of novel clubbed thienyl triazoles was designed which may emerge as potential cdk5/p25 inhibitors, for the treatment of Alzheimer's disease. A benign synthesis was planned so
Takayoshi Nishiya et al.
Toxicology letters, 183(1-3), 81-89 (2008-11-11)
Tienilic acid is reported to be converted into electrophilic metabolites by cytochrome P450 (CYP) in vitro. In vivo, however, the metabolites have not been detected and their effect on liver function is unknown. We previously demonstrated that tienilic acid decreased
M Pilar López-García et al.
Biochemical pharmacology, 70(12), 1870-1882 (2005-11-01)
Drug-induced autoimmune hepatitis is among the most severe hepatic idiosyncratic adverse drug reactions. Considered multifactorial, the disease combines immunological and metabolic aspects, the latter being to date much better known. As for many other model drugs, studies on tienilic acid
S Poli-Scaife et al.
Biochemistry, 36(42), 12672-12682 (1997-10-23)
Purified recombinant human liver cytochrome P450 2C9 was produced, from expression of the corresponding cDNA in yeast, in quantities large enough for UV-visible and 1H NMR experiments. Its interaction with several substrates (tienilic acid and two derivatives, lauric acid and
Takayoshi Nishiya et al.
Toxicology and applied pharmacology, 232(2), 280-291 (2008-08-19)
To investigate the hepatotoxic potential of tienilic acid in vivo, we administered a single oral dose of tienilic acid to Sprague-Dawley rats and performed general clinicopathological examinations and hepatic gene expression analysis using Affymetrix microarrays. No change in the serum
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