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Merck
CN

SML0503

Sigma-Aldrich

9(S)-HODE

≥98% (HPLC)

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别名:
9S-羟基-10E,12Z-十八碳二烯酸
经验公式(希尔记法):
C18H32O3
CAS号:
分子量:
296.44
EC 号:
MDL编号:
UNSPSC代码:
51111800
PubChem化学物质编号:
NACRES:
NA.77

质量水平

检测方案

≥98% (HPLC)

形式

solution

浓度

1 mg/mL in ethanol

颜色

colorless to light yellow

运输

wet ice

储存温度

−20°C

SMILES字符串

CCCCC/C=C\C=C\[C@@H](O)CCCCCCCC(O)=O

InChI

1S/C18H32O3/c1-2-3-4-5-6-8-11-14-17(19)15-12-9-7-10-13-16-18(20)21/h6,8,11,14,17,19H,2-5,7,9-10,12-13,15-16H2,1H3,(H,20,21)/b8-6-,14-11+/t17-/m1/s1

InChI key

NPDSHTNEKLQQIJ-UINYOVNOSA-N

生化/生理作用

9(S)-HODE由亚油酸脂氧化反应生成。它是血浆氧化低密度脂蛋白的主要成分。 9-HODE经证可以通过PPARgamma刺激人系膜细胞的细胞增殖和细胞外基质合成。 9-HODE的促炎效果通过受体GPR132起作用,可促进动脉粥样硬化的进展。9-HODE还经证可以激活脊髓TRPV1,导致炎症性痛觉过敏。

象形图

FlameExclamation mark

警示用语:

Danger

危险声明

危险分类

Eye Irrit. 2 - Flam. Liq. 2

WGK

WGK 1

闪点(°F)

57.2 °F

闪点(°C)

14.0 °C

法规信息

危险化学品

分析证书(COA)

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Shasha Li et al.
Scientific reports, 8(1), 14627-14627 (2018-10-04)
Zhenwu decoction (ZWD) is a promising traditional Chinese prescription against renal fibrosis, while its underlying mechanism remains unclear. Rat model of renal fibrosis were established and divided into control group, model group, ZWD treatment group and enalapril maleate treatment group.
Frédéric Coutant et al.
Journal of immunology (Baltimore, Md. : 1950), 172(1), 54-60 (2003-12-23)
Because of its oxidative modification during the acute-phase response to an aggression, low density lipoprotein (LDL) can be regarded as a source of lipid mediators that can act both to promote and inhibit inflammation. This can be exemplified by the
Edgar B Cahoon et al.
The Journal of biological chemistry, 279(13), 12495-12502 (2004-01-14)
Dimorphecolic acid (9-OH-18:2Delta(10)(trans)(,12)(trans)) is the major fatty acid of seeds of Dimorphotheca species. This fatty acid contains structural features that are not typically found in plant fatty acids, including a C-9 hydroxyl group, Delta(10),Delta(12)-conjugated double bonds, and trans-Delta(12) unsaturation. Expressed
Markus K Muellner et al.
The Biochemical journal, 420(2), 277-281 (2009-03-07)
LOOHs (lipid hydroperoxides) in oxLDL [oxidized LDL (low-density lipoprotein)] are potentially atherogenic compounds. Recently, H2S was identified as the third endogenous gasotransmitter in the vasculature. H2O2 is known to be destroyed by H2S. Assuming that H2S may also react with
[Activation mechanism of PPARgamma by its endogenous ligands].
Takuma Shiraki
Seikagaku. The Journal of Japanese Biochemical Society, 79(10), 960-964 (2007-11-22)

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