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SML0491

Sigma-Aldrich

利托那韦

≥98% (HPLC)

别名:

A-84538, ABT-538, Abbott 84538

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About This Item

经验公式（希尔记法）:
C37H48N6O5S2
CAS号:
155213-67-5
分子量:
720.94
MDL编号:
MFCD00927142
UNSPSC代码:
12352200
PubChem化学物质编号:
329825441
NACRES:
NA.77

质量水平

100

方案

≥98% (HPLC)

表单

powder

颜色

white to beige

溶解性

DMSO: 10 mg/mL (clear solution, warmed)

储存温度

room temp

SMILES字符串

O=C(OCC1=CN=CS1)N[C@H]([C@@H](O)C[C@@H](NC([C@@H](NC(N(CC2=CSC(C(C)C)=N2)C)=O)C(C)C)=O)CC3=CC=CC=C3)CC4=CC=CC=C4

InChI

1S/C37H48N6O5S2/c1-24(2)33(42-36(46)43(5)20-29-22-49-35(40-29)25(3)4)34(45)39-28(16-26-12-8-6-9-13-26)18-32(44)31(17-27-14-10-7-11-15-27)41-37(47)48-21-30-19-38-23-50-30/h6-15,19,22-25,28,31-33,44H,16-18,20-21H2,1-5H3,(H,39,45)(H,41,47)(H,42,46)/t28-,31-,32-,33-/m0/s1

InChI key

NCDNCNXCDXHOMX-XGKFQTDJSA-N

应用

使用利托那韦：
  • 作为人类免疫缺陷病毒（HIV）蛋白酶抑制剂，研究其对胎盘内分泌功能的影响
  • 作为 HIV 蛋白酶抑制剂，研究其对人胚胎肾细胞中四唑染料的还原作用
  • 作为有机阴离子转运多肽（OATP）抑制剂，研究其对香柠檬烯和欧前胡素的肝摄取的影响

生化/生理作用

利托那韦是一种HIV蛋白酶抑制剂，现在经常用作其他蛋白酶抑制剂的加强剂。利托那韦可抑制细胞色素P450-3A4（CYP3A4），其是一种通常可代谢蛋白酶抑制剂的肝酶。它也被研究作为可能的抗癌剂。
利托那韦是一种HIV蛋白酶抑制剂；抗逆转录病毒。

特点和优势

这种化合物是ADME毒性研究的特色产品。点击此处发现更多特色ADME毒性产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302 + H312 + H332

危险分类

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000219883
0000219883
0000209341
0000190743
0000190741

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