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Merck
CN

SML0489

Sigma-Aldrich

BI-87G3

≥98% (HPLC)

别名:

2-(5-Nitrothiazol-2-ylthio)benzo[d]thiazole, 2-[(5-Nitro-2-thiazolyl)thio]-benzothiazole

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About This Item

经验公式(希尔记法):
C10H5N3O2S3
CAS号:
分子量:
295.36
MDL编号:
UNSPSC代码:
12352202
PubChem化学物质编号:
NACRES:
NA.77

方案

≥98% (HPLC)

表单

powder

颜色

white to beige

溶解性

DMSO: 10 mg/mL (clear solution)

储存温度

2-8°C

SMILES字符串

[O-][N+](=O)c1cnc(Sc2nc3ccccc3s2)s1

InChI

1S/C10H5N3O2S3/c14-13(15)8-5-11-9(17-8)18-10-12-6-3-1-2-4-7(6)16-10/h1-5H

InChI key

UHBFMJAKLZGVDS-UHFFFAOYSA-N

生化/生理作用

BI-87G3 is a cell-permeable, potent and selective competitive inhibitor of the c-Jun N-terminal kinase (JNK). BI-87G3 is a JNK inhibitor that targets the JIP-JNK interaction site.
BI-87G3 is a selective and potent c-Jun N-terminal kinase (JNK) inhibitor.

象形图

Exclamation mark

警示用语:

Warning

危险声明

预防措施声明

危险分类

Acute Tox. 4 Oral

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Sphingomyelin phosphodiesterase 3 (SMPD3), a lipid-metabolizing enzyme present in bone and cartilage, has important roles in the developing skeleton. We previously showed that SMPD3 deficiency results in delayed extracellular matrix (ECM) mineralization and severe skeletal deformities in an inducible knockout
Corina A Schmid et al.
The Journal of experimental medicine, 212(5), 775-792 (2015-04-08)
The epigenetic dysregulation of tumor suppressor genes is an important driver of human carcinogenesis. We have combined genome-wide DNA methylation analyses and gene expression profiling after pharmacological DNA demethylation with functional screening to identify novel tumor suppressors in diffuse large

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