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质量水平
方案
≥98% (HPLC)
表单
powder
旋光性
[α]/D +116 to +125°, c = 1 in methanol
储存条件
desiccated
颜色
white to beige
溶解性
H2O: 5 mg/mL (clear solution, warmed)
储存温度
room temp
SMILES字符串
Cl.CNCC[C@H](Oc1cccc2ccccc12)c3cccs3
InChI
1S/C18H19NOS.ClH/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16;/h2-10,13,17,19H,11-12H2,1H3;1H/t17-;/m0./s1
InChI key
BFFSMCNJSOPUAY-LMOVPXPDSA-N
基因信息
human ... SLC6A2(6530) , SLC6A4(6532)
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一般描述
(S)-Duloxetine hydrochloride belongs to the class of serotonin and norepinephrine reuptake inhibitors. Duloxetine is a thiophene derivative. It is used to treat stress urinary incontinence, psychiatric and metabolic disorders. It is also used for treating diabetic peripheral neuropathic pain, fibromyalgia, chronic musculoskeletal and low back pain (LBP). Duloxetine is a cytochrome P450 2D6 (CYP2D6) inhibitor.
应用
(S)-Duloxetine hydrochloride has been used as an antidepressant in rats exposed to chronic mild stress (CMS).
生化/生理作用
盐酸度洛西汀是一种双重血清素/去甲肾上腺素再摄取抑制剂（SNRI），在临床上被广泛用作抗抑郁药和抗焦虑药。
盐酸度洛西汀是一种双重血清素/去甲肾上腺素再摄取抑制剂（SNRI）；抗抑郁药；抗焦虑药。
特点和优势
This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
注意
air sensitive
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
A review of duloxetine 60 mg once-daily dosing for the management of diabetic peripheral neuropathic pain, fibromyalgia, and chronic musculoskeletal pain due to chronic osteoarthritis pain and low back pain
Pergolizzi Jr JV, et al.
Pain Practice : The Official Journal of World Institute of Pain, 13(3), 239-252 (2013)
Mechanisms of pain transmission and pharmacologic management
Argoff C
Current Medical Research and Opinion, 27(10), 2019-2031 (2011)
High-performance liquid chromatographic method for the simultaneous estimation of the key intermediates of duloxetine
Soni P, et al.
Talanta, 67(5), 975-978 (2005)
Modulation of the antioxidant nuclear factor (erythroid 2-derived)-like 2 pathway by antidepressants in rats
Martin-Hernandez D, et al.
Neuropharmacology, 103(3), 79-91 (2016)
David Martín-Hernández et al.
Molecular neurobiology, 56(11), 7522-7533 (2019-05-06)
The standard pharmacological treatment of the major depressive disorder (MDD) is still grounded in a monoaminergic approach. Consequently, antidepressant treatments pursue to heighten serotonergic and noradrenergic neurotransmissions. Thus, the aim of this study was to assess the impact of exposure
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