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主要文件

COO原产地证书/COA分析证书

安全信息

安全和法规

SML0473

Noladin ether

Name: Noladin ether
Brand: SIGMA

≥98% (HPLC)

别名:

2-Arachidonylglyceryl ether, 2-[(5Z,8Z,11Z,14Z)-5,8,11,14-Eicosatetraen-1-yloxy]-1,3-propanediol; 2-AG ether, HU 310

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About This Item

经验公式（希尔记法）:

C₂₃H₄₀O₃

CAS号:

222723-55-9

分子量:

364.56

EC 号:

200-578-6

UNSPSC代码:

12352200

NACRES:

NA.77

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质量水平

100

方案

≥98% (HPLC)

表单

solution

药品控制

regulated under CDSA - not available from Sigma-Aldrich Canada

浓度

10 mg/mL in ethanol (1% w/v)

颜色

colorless to light yellow

运输

dry ice

储存温度

−70°C

SMILES字符串

O(C(CO)CO)CCCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC

InChI

1S/C23H40O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-26-23(21-24)22-25/h6-7,9-10,12-13,15-16,23-25H,2-5,8,11,14,17-22H2,1H3/b7-6-,10-9-,13-12-,16-15-

InChI key

CUJUUWXZAQHCNC-DOFZRALJSA-N

生化/生理作用

Noladin ether (2-Arachidonyl glycerol ether) is a CB1 agonist.

Noladin ether (2-Arachidonyl glycerol ether) is a stable analog of the endogenous cannabanoid 2-Arachidonylglycerol (2-AG) with selectivity for CB1 receptors. Noladin ether is a CB1 agonist. The Ki values for CB1 vs CB2 receptors are 21.2 nM and 3 mM, respectively. Noladin ether induces sedation and has modest antinociceptive activity in vivo, and reduces inter ocular pressure after administration in the eye.