所有图片(1)
About This Item
经验公式（希尔记法）:
C10H7IN2
CAS号:
分子量:
282.08
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
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质量水平
方案
≥97% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 10 mg/mL (clear solution, warmed)
储存温度
−20°C
SMILES字符串
Ic1cc(ncn1)-c2ccccc2
InChI
1S/C10H7IN2/c11-10-6-9(12-7-13-10)8-4-2-1-3-5-8/h1-7H
InChI key
ZTCJXHNJVLUUMR-UHFFFAOYSA-N
应用
在 体外 迁移测定中，4-IPP 已被用作条件培养基 (CM) 中的巨噬细胞的迁移抑制因子 (MIF)。
生化/生理作用
4- IPP是细胞渗透、有效的巨噬细胞迁移抑制因子（MIF）拮抗剂，共价修饰MIF的N末端脯氨酸。
4-碘代-6-苯基嘧啶 (4-IPP) 有可能成为一种新的抗多倍体治疗剂，可在甲状腺癌患者中用于靶向多倍体肿瘤细胞。它可通过阻断IMF-κB途径抑制破骨细胞的生成。4-IPP 可作为巨噬细胞迁移抑制因子 (MIF) 的治疗靶点，用于治疗病理性溶骨性骨病和绝经后骨质流失。它可以阻止肺腺癌细胞的发育和运动，并可以刺激甲状腺癌的细胞凋亡和有丝分裂死亡。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
Yuxin Zhang et al.
Aging, 13(4), 5804-5823 (2021-02-19)
Joint capsule fibrosis caused by excessive inflammation leading to post-traumatic joint contracture (PTJC). Fibroblasts trigger inflammation under the challenge of various proinflammatory cytokines. Macrophage migration inhibitory factor (MIF) is a prominent proinflammatory cytokine involved in inflammation- and fibrosis-associated pathophysiology, we
Sarah Maria Johler et al.
Cancer immunology, immunotherapy : CII, 65(12), 1465-1476 (2016-09-16)
Macrophage migration inhibitory factor (MIF) is known to be involved in oncogenic transformation, tumour progression, and immunosuppression and is overexpressed in many solid tumours, including paediatric rhabdomyosarcoma (RMS). We investigated the function of MIF in RMS during treatment with cytotoxic
Nadège Kindt et al.
Journal of clinical medicine, 8(1) (2019-01-13)
Human papilloma virus (HPV) infection has been well-established as a risk factor in head and neck squamous cell carcinoma (HNSCC). The carcinogenic effect of HPV is mainly due to the E6 and E7 oncoproteins, which inhibit the functions of p53
Kavitha Yaddanapudi et al.
Cancer immunology research, 4(2), 101-112 (2015-11-26)
Highly aggressive cancers "entrain" innate and adaptive immune cells to suppress antitumor lymphocyte responses. Circulating myeloid-derived suppressor cells (MDSC) constitute the bulk of monocytic immunosuppressive activity in late-stage melanoma patients. Previous studies revealed that monocyte-derived macrophage migration inhibitory factor (MIF)
Deepa Rajasekaran et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 28(11), 4961-4971 (2014-07-13)
We report a new inflammatory activity for extracellular d-dopachrome tautomerase (D-DT), the recruitment of neutrophils to the lung on D-DT intratracheal installation of C57BL/6J mice with an EC50 of 5.6 μg. We also find that D-DT and macrophage migration inhibitory
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