所有图片(1)
About This Item
经验公式（希尔记法）:
C8H8Cl2N2S · HCl
CAS号:
分子量:
271.59
MDL编号:
UNSPSC代码:
51111800
PubChem化学物质编号:
NACRES:
NA.77
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质量水平
方案
≥95% (HPLC)
表单
powder
储存条件
desiccated
颜色
white to beige
溶解性
H2O: 2 mg/mL (clear solution, warmed)
储存温度
2-8°C
SMILES字符串
Cl.NC(=N)SCc1ccc(Cl)c(Cl)c1
InChI
1S/C8H8Cl2N2S.ClH/c9-6-2-1-5(3-7(6)10)4-13-8(11)12;/h1-3H,4H2,(H3,11,12);1H
InChI key
VBJNMXMOMSWRDV-UHFFFAOYSA-N
应用
A22盐酸已被用于研究其抗生物膜活性、抗菌、细胞和遗传毒性活性。它也可作为MreB聚合抑制剂用于了解MreB聚合物在白色念珠菌和高假丝酵母念珠菌中的作用。
生化/生理作用
A22是肌动蛋白样细菌蛋白MreB的一种抑制剂，已被证明可作为抗菌佐剂。
A22是肌动蛋白样细菌蛋白MreB的一种抑制剂，已被证明可作为抗菌佐剂。A22对MreB的抑制作用可破坏细菌肌动蛋白的细胞骨架，导致细胞通透性增加和干扰转运。A22已显示出与革兰氏阴性细菌中的数种抗生素具有协同作用，包括新生霉素和利福平。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Alam García-Heredia et al.
eLife, 10 (2021-02-06)
Many antibiotics target the assembly of cell wall peptidoglycan, an essential, heteropolymeric mesh that encases most bacteria. In rod-shaped bacteria, cell wall elongation is spatially precise yet relies on limited pools of lipid-linked precursors that generate and are attracted to
Host-polarized cell growth in animal symbionts.
Pende N, et al.
Current Biology, 28(7), 1039-1051 (2018)
Anti-biofilm activity of A22 ((S-3, 4-dichlorobenzyl) isothiourea hydrochloride) against Pseudomonas aeruginosa: Influence on biofilm formation, motility and bioadhesion.
Bonez P C, et al.
Microbial Pathogenesis, 111, 6-13 (2017)
Antibacterial, cyto and genotoxic activities of A22 compound ((S-3, 4-dichlorobenzyl) isothiourea hydrochloride).
Bonez P C, et al.
Microbial Pathogenesis, 99, 14-18 (2016)
Jan Lennings et al.
International journal of medical microbiology : IJMM, 309(6), 151335-151335 (2019-08-06)
The type VI secretion system (T6SS) injects effector proteins into neighboring bacteria and host cells. Effector translocation is driven by contraction of a tubular sheath in the cytoplasm that expels an inner needle across the cell envelope. The AAA + ATPase ClpV
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