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质量水平
检测方案
≥98% (HPLC)
形式
powder
颜色
white to beige
溶解性
DMSO: 10 mg/mL (clear solution)
储存温度
2-8°C
SMILES字符串
Clc1cccc(Cl)c1C(=O)NCc2ccc3OCOc3c2
InChI
1S/C15H11Cl2NO3/c16-10-2-1-3-11(17)14(10)15(19)18-7-9-4-5-12-13(6-9)21-8-20-12/h1-6H,7-8H2,(H,18,19)
InChI key
NMKJFZCBCIUYHI-UHFFFAOYSA-N
应用
Alda-1 已作为醛脱氢酶 2 (ALDH2) 的激动剂被用于：
- 研究其对 H2O2-诱导的小鼠跟腱病中跟腱细胞的冷冻保护作用
- 研究其对 ALDH2 基因敲除小鼠中酒精衍生 DNA 损伤的保护作用
- 研究其对小鼠皮肤伤口愈合的影响
生化/生理作用
Alda-1 可减轻氧化应激对多种人体细胞（如肺内皮细胞、脐静脉内皮细胞和肝细胞）造成的损伤。
Alda-1 是 ALDH2 激动剂；野生型 ALDH2*1 和亚洲 E487K 突变体 ALDH2*2 形式的线粒体醛脱氢酶 2 的细胞可透过性激活剂。ALDH2 是氧化酶，其除去乙醇代谢物乙醛和其他脂肪醛。同时。 ALDH2 参与血管扩张剂硝酸甘油生物转化为一氧化氮的过程。Alda-1 通过 ALDH2*1（野生型）和 ALDH2*2（亚洲突变体）增加乙醛氧化，分别约 1.5 倍和 6 倍。似乎 Alda-1 通过增强 NAD 结合来刺激 ALDH2 的乙醛氧化，但不增强亚洲突变体的硝酸甘油结合亲和力。
WGK
WGK 3
Jianlu Guo et al.
Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 38(11), 1288-1293 (2018-12-06)
To investigate whether CaN-NFAT3 pathway mediates the protective effects of aldehyde dehydrogenase (ALDH) 2 in high glucose-treated neonatal rat ventricular myocytes. The ventricular myocytes were isolated from the heart of neonatal (within 3 days) SD rats by enzyme digestion and
Fayez T Hammad et al.
Drug development research, 79(7), 315-323 (2018-10-07)
Renal ischemia-reperfusion injury (IRI) induces the production of aldehydes which are detoxified by aldehyde dehydrogenases (ALDHs). Alda-1 is a selective ALDH2 agonist and its protective effect was demonstrated in several conditions. The effect of Alda-1 on the kidney or on
Weiming Yan et al.
BMC ophthalmology, 20(1), 55-55 (2020-02-20)
Retinitis pigmentosa (RP) is a kind of inherited retinal degenerative diseases characterized by the progressive loss of photoreceptors. RP has been a conundrum without satisfactory countermeasures in clinic until now. Acetaldehyde dehydrogenase 2 (ALDH2), a major enzyme involved in aldehyde
Gina D Kusuma et al.
Scientific reports, 7, 42397-42397 (2017-02-17)
High resistance to oxidative stress is a common feature of mesenchymal stem/stromal cells (MSC) and is associated with higher cell survival and ability to respond to oxidative damage. Aldehyde dehydrogenase (ALDH) activity is a candidate "universal" marker for stem cells.
Tingting Fang et al.
Molecular medicine reports, 18(3), 2807-2815 (2018-07-18)
The aim of the present study was to investigate whether necroptosis occurs in high glucose (HG)-induced H9c2 cardiac cell injury and whether the activation of aldehyde dehydrogenase 2 (ALDH2) can inhibit necroptosis. H9c2 cardiac cells were treated with 35 mM glucose
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