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Merck
CN
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SML0450

Sigma-Aldrich

5-BDBD

≥98% (HPLC)

别名:

5-（3-溴苯基）-1,3-二氢-2H-苯并呋喃并[3,2-E] -1,4-二氮杂-2-酮

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About This Item

经验公式（希尔记法）:
C17H11BrN2O2
CAS号:
768404-03-1
分子量:
355.19
MDL编号:
MFCD18086878
UNSPSC代码:
12352200
PubChem化学物质编号:
329824730
NACRES:
NA.77

质量水平

100

方案

≥98% (HPLC)

表单

powder

颜色

white to beige

溶解性

DMSO: 15 mg/mL (clear solution)

储存温度

2-8°C

SMILES字符串

Brc1cccc(c1)C2=NCC(=O)Nc3c2oc4ccccc34

InChI

1S/C17H11BrN2O2/c18-11-5-3-4-10(8-11)15-17-16(20-14(21)9-19-15)12-6-1-2-7-13(12)22-17/h1-8H,9H2,(H,20,21)

InChI key

NKYMVQPXXTZHSF-UHFFFAOYSA-N

生化/生理作用

5-BDBD 是 P2X4 的特异性抑制剂。该化合物抑制 CHO 细胞中的 P2X4 电流，IC50 为 500nM。
在天然组织中，5-BDBD被认为是分析P2X受体（P2XRs）亚型P2X4R作用的有益拮抗剂。

特点和优势

该化合物的相关信息整理于受体分类和信号转导手册的 P2受体：P2X离子通道家族 页面。欲浏览其他手册页面，请 点击这里。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

从最新的版本中选择一种：

分析证书(COA)

Lot/Batch Number
0000361573
0000361573
0000187933
0000187934
0000187934

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Ting Long et al.
Journal of neuroinflammation, 15(1), 245-245 (2018-09-01)
The mechanism underlying migraine chronification remains unclear. Central sensitization may account for this progression. The microglia P2X4 receptor (P2X4R) plays a pivotal role in the central sensitization of inflammatory and neuropathic pain, but there is no information about P2X4R in
Hyuck Joon Kwon et al.
Scientific reports, 6, 39302-39302 (2016-12-23)
Electrical stimulation (ES) is known to guide the development and regeneration of many tissues. However, although preclinical and clinical studies have demonstrated superior effects of ES on cartilage repair, the effects of ES on chondrogenesis remain elusive. Since mesenchyme stem
Claudio Coddou et al.
Neuroscience letters, 690, 219-224 (2018-10-27)
P2X receptors (P2XRs) are a family of ATP-gated ionic channels that are expressed in numerous excitable and non-excitable cells. Despite the great advance on the structure and function of these receptors in the last decades, there is still lack of
Andreas Zech et al.
Oncotarget, 7(49), 80288-80297 (2016-11-20)
Compelling evidences point out a crucial role for extracellular nucleotides such as adenosine triphosphate (ATP) during inflammatory conditions. Once released into the extracellular space, ATP modulates migration, maturation and function of various inflammatory cells via activating of purinergic receptors of
Yun-Ming Tu et al.
Food & function, 8(12), 4336-4346 (2017-09-25)
Circulating levels of free fatty acids (FFAs) are often found to be increased in patients with type 2 diabetes mellitus (T2DM) and metabolic syndrome (MS). High plasma FFA levels may give rise to maladaptive macrophage activation and promote inflammatory responses
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