推荐产品
方案
≥97% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 15 mg/mL (clear solution)
储存温度
room temp
SMILES字符串
Oc1cc(Cl)cc(c1)C(O)=O
InChI
1S/C7H5ClO3/c8-5-1-4(7(10)11)2-6(9)3-5/h1-3,9H,(H,10,11)
InChI key
RJOLIYHZZKAIET-UHFFFAOYSA-N
生化/生理作用
3-Chloro-5-hydroxybenzoic acid is a selective agonist of the lactate receptor, GPR81.
3-Chloro-5-hydroxybenzoic acid is a selective agonist of the lactate receptor, GPR81. Stimulation of either GPR81 or GPR109a in adipose tissue leads to a similar decrease in triglyceride lipolysis. Niacin is used to treat dyslipidemia via its agonism of GPR109a, but compliance is low due to side effects (flushing and pruritus), which are associated with GPR109a agonism. 3-Chloro-5-hydroxybenzoic acid is selective for GPR81 over other GPCRs, including GPR109a. While less potent than niacin (16 vs. 0.78 μM), it has similar activity as the same dose as niacin in animal studies and should not cause the flushing that is associated with niacin.
警示用语：
Danger
危险分类
Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Timothy P Brown et al.
Oncogene, 39(16), 3292-3304 (2020-02-20)
GPR81 is a G-protein-coupled receptor for lactate, which is upregulated in breast cancer and plays an autocrine role to promote tumor growth by tumor cell-derived lactate. Here we asked whether lactate has any paracrine role via activation of GPR81 in
Marvin Lambertus et al.
Acta physiologica (Oxford, England), 231(3), e13587-e13587 (2020-11-28)
Adult neurogenesis occurs in two major niches in the brain: the subgranular zone of the hippocampal formation and the ventricular-subventricular zone. Neurogenesis in both niches is reduced in ageing and neurological disease involving dementia. Exercise can rescue memory by enhancing
Rafaz Hoque et al.
Gastroenterology, 146(7), 1763-1774 (2014-03-25)
The NACHT, LRR, and pyrin domain-containing protein 3 (NLRP3) inflammasome induces inflammation in response to organ injury, but little is known about its regulation. Toll-like receptors (TLRs) provide the first signal required for activation of the inflammasome and stimulate aerobic
Haíssa de Castro Abrantes et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 39(23), 4422-4433 (2019-03-31)
The discovery of a G-protein-coupled receptor for lactate named hydroxycarboxylic acid receptor 1 (HCAR1) in neurons has pointed to additional nonmetabolic effects of lactate for regulating neuronal network activity. In this study, we characterized the intracellular pathways engaged by HCAR1
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