推荐产品
产品名称
SU-5402, ≥98% (HPLC)
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
light yellow to dark orange
溶解性
DMSO: 10 mg/mL (clear solution)
储存温度
−20°C
SMILES字符串
Cc1c[nH]c(\C=C2/C(=O)Nc3ccccc23)c1CCC(O)=O
InChI
1S/C17H16N2O3/c1-10-9-18-15(11(10)6-7-16(20)21)8-13-12-4-2-3-5-14(12)19-17(13)22/h2-5,8-9,18H,6-7H2,1H3,(H,19,22)(H,20,21)/b13-8-
InChI key
JNDVEAXZWJIOKB-JYRVWZFOSA-N
1 of 4
此商品 | OGS621 | OGS620 | OGS619 |
|---|---|---|---|
| peptide cleavage EKT | peptide cleavage EKT | peptide cleavage EKT | peptide cleavage EKT |
| origin of replication pUC | origin of replication pUC | origin of replication pUC | origin of replication pUC |
| peptide tag location N-terminal | peptide tag location N-terminal | peptide tag location N-terminal | peptide tag location C-terminal |
| bacteria selection ampicillin | bacteria selection ampicillin | bacteria selection ampicillin | bacteria selection ampicillin |
| mol wt size 5913 bp | mol wt size 4610 bp | mol wt size 4568 bp | mol wt size 4530 bp |
应用
生化/生理作用
SU-5402 对酪氨酸激酶的活动具有抑制作用。与成纤维细胞生长因子受体 (FGFR) 上的 ATP 结合站点竞争性结合。[5]
SU-5402 是一种 FGFR 拮抗剂和血管生成抑制剂。
SU-5402 是一种 FGFR 拮抗剂；血管生成抑制剂。
特点和优势
该化合物是激酶磷酸酶生物学研究的特色产品。 点击此处 ，发现更多特色激酶磷酸酶生物学产品。前往 sigma.com/discover-bsm了解更多关于其他研究领域的生物活性小分子。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
BMP2/Smad signaling pathway is involved in the inhibition function of fibroblast growth factor 21 on vascular calcification
Liu X, et al.
Biochemical and Biophysical Research Communications, 503, 930-937 (2018)
Fibroblast growth factor 21 plays an inhibitory role in vascular calcification in vitro through OPG/RANKL system
Cao F, et al.
Biochemical and Biophysical Research Communications, 491(3), 578-586 (2017)
Existence of muscarinic acetylcholine receptor (mAChR) and fibroblast growth factor receptor (FGFR) heteroreceptor complexes and their enhancement of neurite outgrowth in neural hippocampal cultures
Di LV, et al.
Biochim. Biophys. Acta Gen. Subj., 1861(2), 235-245 (2017)
Fang Liang et al.
Scientific reports, 5, 14468-14468 (2015-10-09)
Natural products are a rich resource for the discovery of therapeutic substances. By directly using 504 fine fractions from isolated traditional Chinese medicine plants, we performed a transgenic zebrafish based screen for anti-angiogenesis substances. One fraction, DYVE-D3, was found to
Fibroblast growth factor (FGF)-23 inhibits renal phosphate reabsorption by activation of the mitogen-activated protein kinase pathway
Yamashita T, et al.
The Journal of Biological Chemistry, 277(31), 28265-28270 (2002)
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