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质量水平
方案
≥95% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 5 mg/mL (clear solution)
储存温度
−20°C
SMILES字符串
Nc1nc(N)c(SC#N)cc1SC#N
InChI
1S/C7H5N5S2/c8-2-13-4-1-5(14-3-9)7(11)12-6(4)10/h1H,(H4,10,11,12)
InChI key
ZXOBLNBVNROVLC-UHFFFAOYSA-N
应用
PR-619已被用于：
- 作为裂解缓冲液的成分，以及用作去泛素化酶抑制剂用于处理来源于SILAC-标记Jurkat 细胞的蛋白质
- 作为去泛素化酶抑制剂用于研究其对腺相关病毒 (AAV) 转导的影响
- 用于泛素化检测用放射免疫沉淀测定缓冲液 (RIPA)
生化/生理作用
PR-619 是一种细胞可透过性广谱去泛素化酶（DBUs）抑制剂。PR-619 在不直接影响蛋白酶体活性的情况下，诱导细胞中多泛素化蛋白质的积聚。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
Anne Garreau et al.
Journal of immunology (Baltimore, Md. : 1950), 199(8), 2758-2766 (2017-09-08)
Themis is a new component of the TCR signaling machinery that plays a critical role during T cell development. The positive selection of immature CD4
Tyler Bland et al.
Endocrinology, 160(8), 1982-1998 (2019-06-15)
Leptin has neurotrophic actions in the hippocampus to increase synapse formation and stimulate neuronal plasticity. Leptin also enhances cognition and has antidepressive and anxiolytic-like effects, two hippocampal-dependent behaviors. In contrast, mice lacking leptin or the long form of the leptin
Large-scale identification of ubiquitination sites by mass spectrometry
Udeshi ND, et al.
Nature Protocols, 8(10), 1950-1950 (2013)
Cytosolic iron-sulfur assembly is evolutionarily tuned by a cancer-amplified ubiquitin ligase
Weon JL, et sl.
Molecular Cell, 69(1), 113-125 (2018)
Hirotaka Takahashi et al.
Biomedicines, 8(6) (2020-06-10)
Protein ubiquitinations play pivotal roles in many cellular processes, including homeostasis, responses to various stimulations, and progression of diseases. Deubiquitinating enzymes (DUBs) remove ubiquitin molecules from ubiquitinated proteins and cleave the polyubiquitin chain, thus negatively regulating numerous ubiquitin-dependent processes. Dysfunctions
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