跳转至内容
Merck
CN

SML0421

Sigma-Aldrich

SB265610

≥98% (HPLC)

登录查看公司和协议定价

别名:
1-(2-溴苯基)-3-(4-氰基-1H-苯并[d][1,2,3]三唑-7-基)脲, N-(2-溴苯基)-N′-(7-氰基-1H-苯并三唑-4-基)脲, SB 265610
经验公式(希尔记法):
C14H9BrN6O
分子量:
357.16
MDL编号:
UNSPSC代码:
51111800
PubChem化学物质编号:
NACRES:
NA.77

质量水平

检测方案

≥98% (HPLC)

形式

powder

颜色

white to light brown

溶解性

DMSO: 15 mg/mL, clear

储存温度

2-8°C

SMILES字符串

Brc1ccccc1NC(=O)Nc2ccc(C#N)c3nn[nH]c23

InChI

1S/C14H9BrN6O/c15-9-3-1-2-4-10(9)17-14(22)18-11-6-5-8(7-16)12-13(11)20-21-19-12/h1-6H,(H2,17,18,22)(H,19,20,21)

InChI key

SEDUMQWZEOMXSO-UHFFFAOYSA-N

应用

SB265610已用于:
  • 作为一种半胱氨酸-氨基酸-半胱氨酸(CXC)-趋化因子受体2(CXCR2)拮抗剂,研究其对趋化因子与G蛋白偶联受体(GPCR)结合的影响
  • 作为一种CXC-趋化因子受体1(CXCR1)抑制剂,研究其对炎症细胞趋化因子趋化活性的影响
  • 作为一种CXCR2拮抗剂,研究其对中性粒细胞向大鼠脑内迁移的影响

生化/生理作用

SB265610是一种强效、选择性CXCR2趋化因子受体拮抗剂。 其Kd = 2.5 nM。

特点和优势

《受体分类和信号转导》手册的 趋化因子受体页有该化合物的介绍。想要浏览手册的其他页面, 请单击此处

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Acute Tox. 4 Oral

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ (Lot或Batch)字后找到。

已有该产品?

在文件库中查找您最近购买产品的文档。

访问文档库

Julia Esser-von Bieren et al.
PLoS pathogens, 11(3), e1004778-e1004778 (2015-03-26)
Helminth parasites can cause considerable damage when migrating through host tissues, thus making rapid tissue repair imperative to prevent bleeding and bacterial dissemination particularly during enteric infection. However, how protective type 2 responses targeted against these tissue-disruptive multicellular parasites might
Meirong Du et al.
PloS one, 8(1), e54572-e54572 (2013-01-30)
Recent evidence indicates that CXCR2 signaling is crucial for cancer progression, and its antagonist SB225002 induces apoptosis in Wilms' tumor cells. Here, we investigated the effect of SB225002 on cell cycle progression and apoptosis induction in vitro, using CDDP-sensitive and
Jing Zhao et al.
Scientific reports, 7(1), 16128-16128 (2017-11-25)
The pulsatile nature of blood flow exposes vascular smooth muscle cells (VSMCs) in the vessel wall to cyclic mechanical stretch (CMS), which evokes VSMC proliferation, cell death, phenotypic switching, and migration, leading to vascular remodeling. These responses have been observed
François Binet et al.
Science (New York, N.Y.), 369(6506) (2020-08-21)
In developed countries, the leading causes of blindness such as diabetic retinopathy are characterized by disorganized vasculature that can become fibrotic. Although many such pathological vessels often naturally regress and spare sight-threatening complications, the underlying mechanisms remain unknown. Here, we
Zongmin Jiang et al.
Scientific reports, 7(1), 14510-14510 (2017-11-08)
Microenvironment (or niche)-providing chemokines regulate many important biological functions of tissue-specific stem cells. However, to what extent chemokines influence human pluripotent stem cells (hPSCs) is not yet completely understood. In this study, we applied protein array to screen chemokines found

商品

We offer many products related to chemokine receptors for your research needs.

我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门