推荐产品
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to light brown
溶解性
DMSO: 15 mg/mL, clear
储存温度
2-8°C
SMILES字符串
Brc1ccccc1NC(=O)Nc2ccc(C#N)c3nn[nH]c23
InChI
1S/C14H9BrN6O/c15-9-3-1-2-4-10(9)17-14(22)18-11-6-5-8(7-16)12-13(11)20-21-19-12/h1-6H,(H2,17,18,22)(H,19,20,21)
InChI key
SEDUMQWZEOMXSO-UHFFFAOYSA-N
应用
SB265610已用于：
- 作为一种半胱氨酸-氨基酸-半胱氨酸（CXC）-趋化因子受体2（CXCR2）拮抗剂，研究其对趋化因子与G蛋白偶联受体（GPCR）结合的影响
- 作为一种CXC-趋化因子受体1（CXCR1）抑制剂，研究其对炎症细胞趋化因子趋化活性的影响
- 作为一种CXCR2拮抗剂，研究其对中性粒细胞向大鼠脑内迁移的影响
生化/生理作用
SB265610是一种强效、选择性CXCR2趋化因子受体拮抗剂。
SB265610是一种强效、选择性CXCR2趋化因子受体拮抗剂。 其Kd = 2.5 nM。
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Meirong Du et al.
PloS one, 8(1), e54572-e54572 (2013-01-30)
Recent evidence indicates that CXCR2 signaling is crucial for cancer progression, and its antagonist SB225002 induces apoptosis in Wilms' tumor cells. Here, we investigated the effect of SB225002 on cell cycle progression and apoptosis induction in vitro, using CDDP-sensitive and
Julia Esser-von Bieren et al.
PLoS pathogens, 11(3), e1004778-e1004778 (2015-03-26)
Helminth parasites can cause considerable damage when migrating through host tissues, thus making rapid tissue repair imperative to prevent bleeding and bacterial dissemination particularly during enteric infection. However, how protective type 2 responses targeted against these tissue-disruptive multicellular parasites might
Jing Zhao et al.
Scientific reports, 7(1), 16128-16128 (2017-11-25)
The pulsatile nature of blood flow exposes vascular smooth muscle cells (VSMCs) in the vessel wall to cyclic mechanical stretch (CMS), which evokes VSMC proliferation, cell death, phenotypic switching, and migration, leading to vascular remodeling. These responses have been observed
Tao Zhang et al.
European journal of immunology, 48(6), 1059-1073 (2018-02-21)
Endometriosis affects women of reproductive age via unclear immunological mechanism(s). Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of myeloid cells with potent immunosuppressive and angiogenic properties. Here, we found MDSCs significantly increased in the peripheral blood of patients with
Zongmin Jiang et al.
Scientific reports, 7(1), 14510-14510 (2017-11-08)
Microenvironment (or niche)-providing chemokines regulate many important biological functions of tissue-specific stem cells. However, to what extent chemokines influence human pluripotent stem cells (hPSCs) is not yet completely understood. In this study, we applied protein array to screen chemokines found
商品
We offer many products related to chemokine receptors for your research needs.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门