SML0417
Costunolide
≥97% (HPLC), apoptosis inducer, powder
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关于此项目
经验公式（希尔记法）:
C15H20O2
化学文摘社编号:
分子量:
232.32
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
Costunolide, ≥97% (HPLC)
SMILES string
C\C1=C/CC\C(C)=C\[C@H]2OC(=O)C(=C)[C@@H]2CC1
InChI
1S/C15H20O2/c1-10-5-4-6-11(2)9-14-13(8-7-10)12(3)15(16)17-14/h5,9,13-14H,3-4,6-8H2,1-2H3/b10-5+,11-9+/t13-,14+/m0/s1
InChI key
HRYLQFBHBWLLLL-AHNJNIBGSA-N
assay
≥97% (HPLC)
form
powder
optical activity
[α]/D +110.0 to +130.0°, c = 0.5 in chloroform-d
color
white to beige
solubility
DMSO: 10 mg/mL (clear solution)
storage temp.
−20°C
Quality Level
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General description
Costunolide has anti-ulcer and antipyretic properties. It inhibits the cellular proliferation of melanin, human lamin-B by farnesyl-protein transferase (FPTase) and protein tyrosine phosphatase 1B (hPTP1B). Costunolide has strong larvicidal activity against A.albopictus. It inhibits the expression of inducible nitric oxide synthase and DNA-binding activity of nuclear factor kappa B subunit (NF-κB). It might function as a natural herbicide.
Application
Costunolide has been used to study its effects in allergic asthma using female Balb/c mice and rat basophilic leukemia (RBL)-2H3 mast cells.
Biochem/physiol Actions
Costunolide is a potent inducer of apoptosis and potent anti-cancer agent. Costunolide has anti-inflammatory, anti-viral, anti-fungal, antimycobacterial activity and inhibits telomerase activity.
Costunolide is a sesquiterpene lactone originally isolated from plants widely used in many herbal medicines. It has a variety of effects. Costunolide is a potent inducer of apoptosis, a potent anti-cancer agent, has anti-inflammatory, anti-viral, anti-fungal, antimycobacterial activity and has been shown to inhibit telomerase activity.
signalword
Warning
hcodes
Hazard Classifications
Skin Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Azhar Rasul et al.
Molecules (Basel, Switzerland), 18(2), 1418-1433 (2013-01-26)
Despite the availability of several therapeutic options, a safer and more effective modality is urgently needed for treatment of bladder cancer. Costunolide, a member of sesquiterpene lactone family, possesses potent anticancer properties. In this study, for the first time we
Nobuhiro Ikezawa et al.
The Journal of biological chemistry, 286(24), 21601-21611 (2011-04-26)
Sesquiterpene lactones (STLs) are terpenoid natural products possessing the γ-lactone, well known for their diverse biological and medicinal activities. The occurrence of STLs is sporadic in nature, but most STLs have been isolated from plants in the Asteraceae family. Despite
Costunolide: A novel anti Costunolide: A novel anti-cancer sesquiterpene lactone cancer sesquiterpene lactone cancer sesquiterpene lactone
Rasul A, et al.
Bangladesh Journal of Pharmacology, 7, 6-13 (2012)
Ha Si et al.
PloS one, 15(4), e0231466-e0231466 (2020-04-17)
DaHuangWan (DHW) is a traditional herbal medicine used by Mongolian to treat liver cancer for many years. Clinical application of the drug has been shown to help control tumor progression, prolong survival and improve quality of life. However, the underlying
Giovanni Appendino et al.
Journal of natural products, 72(3), 340-344 (2008-12-05)
The sesterpene gamma-lactone genepolide (5) has been isolated from a Swiss horticultural variety of mountain wormwood (Artemisia umbelliformis) developed as a thujones-free alternative to native Western Alps wormwoods for the production of liqueurs. Genepolide is the formal Diels-Alder adduct of
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