SML0409
STF-083010
≥98% (HPLC)
别名:
N-[（2-羟基-1-萘基）亚甲基]-2-噻吩磺酰胺
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关于此项目
经验公式（希尔记法）:
C15H11NO3S2
化学文摘社编号:
分子量:
317.38
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
light yellow to yellow-green
溶解性
DMSO: 5 mg/mL (clear solution)
储存温度
−20°C
SMILES字符串
OC1=C(/C=N/S(C2=CC=CS2)(=O)=O)C3=C(C=CC=C3)C=C1
InChI
1S/C15H11NO3S2/c17-14-8-7-11-4-1-2-5-12(11)13(14)10-16-21(18,19)15-6-3-9-20-15/h1-10,17H/b16-10+
InChI key
TVIVJHZHPKNDAQ-MHWRWJLKSA-N
相关类别
应用
STF-083010 已被用于：
- 研究烟酰胺的潜在抗脂肪毒性作用，并阐明基本机制
- 作为IRE1a抑制剂研究其对NOS 2表达的作用并考察促炎基因在星形细胞中表达的基本机制
- 在棕榈酸盐暴露前一小时阻断内源性XBP1裂解从而考察肌醇需求酶 1α (IRE1α ) 激活是否与棕榈酸盐细胞毒性有关。
生化/生理作用
STF-083010是ER跨膜蛋白IRE1的有效抑制剂，其可介导未折叠的蛋白质反应。STF-083010可抑制IRE1内切核酸酶和mRNA剪接活性以响应内质网（ER）应激，但对IRE1的激酶活性没有影响。
STF-083010是IRE-1 mRNA剪接活性的有效抑制剂。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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