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Merck
CN

SML0409

Sigma-Aldrich

STF-083010

≥98% (HPLC)

别名:

N-[(2-羟基-1-萘基)亚甲基]-2-噻吩磺酰胺

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About This Item

经验公式(希尔记法):
C15H11NO3S2
分子量:
317.38
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77

质量水平

方案

≥98% (HPLC)

表单

powder

颜色

light yellow to yellow-green

溶解性

DMSO: 5 mg/mL (clear solution)

储存温度

−20°C

SMILES字符串

OC1=C(/C=N/S(C2=CC=CS2)(=O)=O)C3=C(C=CC=C3)C=C1

InChI

1S/C15H11NO3S2/c17-14-8-7-11-4-1-2-5-12(11)13(14)10-16-21(18,19)15-6-3-9-20-15/h1-10,17H/b16-10+

InChI key

TVIVJHZHPKNDAQ-MHWRWJLKSA-N

应用

STF-083010 已被用于:
  • 研究烟酰胺的潜在抗脂肪毒性作用,并阐明基本机制
  • 作为IRE1a抑制剂研究其对NOS 2表达的作用并考察促炎基因在星形细胞中表达的基本机制
  • 在棕榈酸盐暴露前一小时阻断内源性XBP1裂解从而考察肌醇需求酶 1α (IRE1α ) 激活是否与棕榈酸盐细胞毒性有关。

生化/生理作用

STF-083010是ER跨膜蛋白IRE1的有效抑制剂,其可介导未折叠的蛋白质反应。STF-083010可抑制IRE1内切核酸酶和mRNA剪接活性以响应内质网(ER)应激,但对IRE1的激酶活性没有影响。
STF-083010是IRE-1 mRNA剪接活性的有效抑制剂。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Nicotinamide protects hepatocytes against palmitate-induced lipotoxicity via SIRT1-dependent autophagy induction
Shen C, et al.
Nutrition Research (New York, N.Y.), 40, 40-47 (2017)
The TLR 4-IRE 1alpha pathway activation contributes to palmitate-elicited lipotoxicity in hepatocytes
Shen C, et al.
Journal of Cellular and Molecular Medicine, 22(7), 3572-3581 (2018)
Environmental Control of Astrocyte Pathogenic Activities in CNS Inflammation
Wheeler MA, et al.
Cell, 176(3), 581-596 (2019)
Margaud Iovino et al.
Frontiers in immunology, 14, 1204126-1204126 (2023-09-15)
In obesity, adipose tissue infiltrating macrophages acquire a unique pro-inflammatory polarization, thereby playing a key role in the development of chronic inflammation and Type 2 diabetes. Increased saturated fatty acids (SFAs) levels have been proposed to drive this specific polarization.
Carley J S Heck et al.
Molecular pharmacology, 95(2), 183-195 (2018-11-18)
Efavirenz (EFV), a widely used antiretroviral drug, is associated with idiosyncratic hepatotoxicity and dyslipidemia. Here we demonstrate that EFV stimulates the activation in primary hepatocytes of key cell stress regulators: inositol-requiring 1α (IRE1α) and X-box binding protein 1 (XBP1). Following

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