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质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 10 mg/mL (clear solution)
储存温度
2-8°C
SMILES字符串
NC(=O)c1nnn(Cc2cc(Cl)c(c(Cl)c2)C(=O)c3ccc(Cl)cc3)c1N
InChI
1S/C17H12Cl3N5O2/c18-10-3-1-9(2-4-10)15(26)13-11(19)5-8(6-12(13)20)7-25-16(21)14(17(22)27)23-24-25/h1-6H,7,21H2,(H2,22,27)
InChI key
WNRZHQBJSXRYJK-UHFFFAOYSA-N
生化/生理作用
羧胺三唑（CAI）是一种没有细胞毒性的抗癌药物。它具有抗炎特性，并减少促炎细胞因子的释放。CAI可以在体外和体内阻止多种人类癌细胞和内皮细胞的增殖和侵袭行为。它可用于治疗多种急性和慢性炎症模型，如佐剂性关节炎和炎症性肠病（IBD）。CAI在体外阻断肿瘤细胞增殖并刺激细胞凋亡。
羧酰氨基三唑（L-651582）是一种口服活性钙通道阻滞剂。羧酰氨基三唑阻断细胞内和线粒体钙的进入和通量，从而抑制细胞增殖、激活钙释放激活的钙通道（CRAC）功能并维持线粒体膜电位。
警示用语：
Danger
危险声明
危险分类
Acute Tox. 3 Oral
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
Hui Song et al.
Frontiers in microbiology, 8, 1419-1419 (2017-08-12)
Codon usage bias plays an important role in shaping genomes and genes in unicellular species and multicellular species. Here, we first analyzed codon usage bias in seven
Andreia S P Sousa et al.
Scientific reports, 9(1), 3115-3115 (2019-03-01)
This study aims to: (1) to compare 2 methods of assessing the timing of medium latency responses (MLR), in regard to intrasession reliability and mean values, in subjects with and without chronic ankle instability (CAI), and (2) to analyze the
Lars P J Cruysberg et al.
Retina (Philadelphia, Pa.), 25(8), 1022-1031 (2005-12-13)
To evaluate the human transscleral diffusion and intravitreal delivery of carboxyamido-triazole (CAI) and 2-Methoxyestradiol (2ME2). The transscleral diffusion of two retinal antiangiogenic molecules, CAI and 2ME2, was measured in vitro to assess their potential transscleral delivery. Varying concentrations and different
Kevin Deschamps et al.
Clinical biomechanics (Bristol, Avon), 54, 1-7 (2018-03-05)
Investigate differences in multi-segment foot kinematics between controls and participants with chronic ankle instability during running with a midfoot striking pattern and to evaluate the effect of Low-Dye and High-Dye taping. Three-dimensional multi-segment foot kinematics of 12 controls and 15
Xiaowan Du et al.
International immunopharmacology, 45, 16-25 (2017-02-06)
Excess proinflammatory cytokines owing to the activation of NF-κB and NLRP3 inflammasome play the key role in inflammatory bowel disease (IBD). Previously, we reported the anti-inflammatory activity of carboxyamidotriazole (CAI) resulting from decreasing cytokines. Therefore, we investigated the therapeutic effects
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