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质量水平
检测方案
≥98% (HPLC)
形式
powder
颜色
white to beige
溶解性
DMSO: 5 mg/mL (warmed, clear solution)
储存温度
2-8°C
SMILES字符串
NS(C1=CC=C(C=C1)N2N=C(C3=CC=CC=C3)CC2C4=CC=C(OC)C=C4)(=O)=O
InChI
1S/C22H21N3O3S/c1-28-19-11-7-17(8-12-19)22-15-21(16-5-3-2-4-6-16)24-25(22)18-9-13-20(14-10-18)29(23,26)27/h2-14,22H,15H2,1H3,(H2,23,26,27)
InChI key
QBNZBMVRFYREHK-UHFFFAOYSA-N
应用
ML 141 已被用于：
- 抑制人永生化牙龈上皮 (HIGE) 细胞中的 CDC42 gtp 酶
- 作为 Rho 激酶的抑制剂研究小 Rho gtp 酶对外周细胞核定位的作用
- 作为肌动蛋白调节因子抑制剂，确定哪些肌动蛋白调节因子和成核因子参与损伤线粒体周围 F-actin 笼的组装
- 作为 ccdc42 的选择性、非竞争性抑制剂处理 CCD-1070Sk 细胞角色
生化/生理作用
141 是 Rho 家族 gtp 酶 cdc42 的强效、选择性抑制剂。抑制酶活性的 IC 50 为 200 nM，对 Rho 家族成员 Rac、Ras 或 Rab 无活性。通过与神经 Wiskott-Aldrich 综合征蛋白 (N-WASP) 的直接结合，Cdc42 参与了肌动蛋白聚合的调控，随后可激活 Arp2/3 复合物。该复合物介导肌动蛋白聚合成分支网络，并调节重要功能包括细胞粘附、细胞骨架排列、吞噬作用和宿主-病原体相互作用、运动、迁移和膜蛋白运输。
特点和优势
《受体分类和信号转导》手册的 GTP 结合蛋白（低分子量） 页面有该化合物的介绍。想要浏览手册的其他页面， 请单击此处。
这种化合物是环核苷酸研究的特色产品。点击此处发现更多特色环核苷酸产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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