SML0370
岩白菜素
≥98% (HPLC), runt-related transcription factor 1 (RUNX1) regulator, powder
别名:
2-[（联苯-4-基）氨甲酰基] 苯甲酸, 4′-苯基邻苯二甲酸 (8CI), KGN
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关于此项目
经验公式（希尔记法）:
C20H15NO3
化学文摘社编号:
分子量:
317.34
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
岩白菜素, ≥98% (HPLC)
SMILES string
O=C(NC1=CC=C(C2=CC=CC=C2)C=C1)C(C=CC=C3)=C3C(O)=O
InChI
1S/C20H15NO3/c22-19(17-8-4-5-9-18(17)20(23)24)21-16-12-10-15(11-13-16)14-6-2-1-3-7-14/h1-13H,(H,21,22)(H,23,24)
InChI key
SLUINPGXGFUMLL-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
solubility
DMSO: >15 mg/mL
storage temp.
room temp
Quality Level
相关类别
Biochem/physiol Actions
Kartogenin 诱导多能间充质干细胞 (MSCs) 选择性分化为软骨细胞。
Kartogenin 诱导多能间充质干细胞 (MSCs) 选择性分化为软骨细胞。Kartogenin 与细丝蛋白 A 结合，破坏了细丝蛋白 A 和 CBFβ 之间的特异性相互作用（核心结合因子 β亚单位）。显然，kartogenin 通过调节 CBFβ 的核定位诱导软骨形成.
Kartogenin是小杂环化合物。它参与Runt相关转录因子1(RUNX1)的调节，在软骨细胞增殖和存活中起重要作用。
存储类别
11 - Combustible Solids
wgk
WGK 3
Hui Li et al.
Endocrinology, 159(4), 1644-1657 (2018-02-21)
Transforming growth factor-β (TGF-β) 1 plays a critical role in regulating follicular development, and its dysregulation has been shown to be involved in the pathogenesis of ovulation dysfunction. SNAIL is a well-known transcriptional repressor that mediates TGF-β1-induced cellular functions. Pentraxin
Hanyong Jin et al.
PloS one, 11(7), e0159112-e0159112 (2016-07-16)
Anti-Müllerian hormone (AMH) is required for proper sexual differentiation by regulating the regression of the Müllerian ducts in males. Recent studies indicate that AMH could be an important factor for maintaining the ovarian reserve. However, the mechanisms of AMH regulation
Yoshitaka Imamichi et al.
Scientific reports, 7(1), 8374-8374 (2017-08-23)
Diethylstilbestrol (DES), a strong estrogenic compound, is well-known to affect the reproductive system. In this study, we investigated the effects of DES administration on gonadotropin levels and ovarian steroidogenesis in prepubertal rats. DES treatment acutely reduced serum LH levels, followed
Jianying Zhang et al.
Bone research, 2 (2014-11-25)
Tendon-bone junctions (TBJs) are frequently injured, especially in athletic settings. Healing of TBJ injuries is slow and is often repaired with scar tissue formation that compromises normal function. This study explored the feasibility of using kartogenin (KGN), a biocompound, to
Dongquan Shi et al.
ACS nano, 10(1), 1292-1299 (2016-01-13)
The regeneration of cartilage, an aneural and avascular tissue, is often compromised by its lack of innate abilities to mount a sufficient healing response. Kartogenin (KGN), a small molecular compound, can induce bone marrow-derived mesenchymal stem cells (BMSCs) into chondrocytes.
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