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Merck
CN

SML0364

Sigma-Aldrich

RAD51抑制剂B02

≥98% (HPLC)

别名:

3-(苯甲基)-2-[(1E)-2-(3-吡啶基)乙烯基]-4(3H)-喹唑啉酮

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About This Item

经验公式(希尔记法):
C22H17N3O
分子量:
339.39
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77

质量水平

方案

≥98% (HPLC)

表单

powder

颜色

white to dark brown

溶解性

DMSO: ≥5 mg/mL

储存温度

2-8°C

SMILES字符串

O=C1N(CC2=CC=CC=C2)C(/C=C/C3=CN=CC=C3)=NC4=C1C=CC=C4

InChI

1S/C22H17N3O/c26-22-19-10-4-5-11-20(19)24-21(13-12-17-9-6-14-23-15-17)25(22)16-18-7-2-1-3-8-18/h1-15H,16H2/b13-12+

InChI key

GEKDQXSPTHHANP-OUKQBFOZSA-N

应用

RAD51 抑制剂B02已被用于:
  • 测试其对猪卵母细胞极体排放(PBE)率的影响
  • 用于猪胚胎的RAD51抑制
  • 作为RAD51 抑制剂并用于测试其对诱导多能干细胞 (iPSC) 中靶向氨基酸替换 (TNS) 的影响

生化/生理作用

B02 (3-(苯甲基)-2-[(1E)-2-(3-吡啶基)乙烯基]-4(3H)-喹唑啉酮是一种吡啶基乙烯基喹唑啉酮化合物,可以穿透细胞。B02抑制人RAD51重组酶及之后核线的形成。它可以中止癌细胞中的同源重组(HR)修复活动。B02促进多发性骨髓瘤中的细胞凋亡,同时也是敏化多柔比星的关键。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

RAD51 maintains chromosome integrity and mitochondrial distribution during porcine oocyte maturation in vitro
Jin ZL and Kim NH
Journal of Reproduction and Development (2017)
A small-molecule inhibitor of RAD51 reduces homologous recombination and sensitizes multiple myeloma cells to doxorubicin
Alagpulinsa DA, et al.
Frontiers in Oncology, 4, 289-289 (2014)
Inhibition of DNA repair protein RAD51 affects porcine preimplantation embryo development
Jin ZL, et al.
Reproduction (Cambridge, England), 157(3) (2019)
Ivana Murfuni et al.
PLoS genetics, 9(10), e1003910-e1003910 (2013-11-10)
In checkpoint-deficient cells, DNA double-strand breaks (DSBs) are produced during replication by the structure-specific endonuclease MUS81. The mechanism underlying MUS81-dependent cleavage, and the effect on chromosome integrity and viability of checkpoint deficient cells is only partly understood, especially in human
Arthur Aubry et al.
Oncogene, 39(31), 5338-5357 (2020-06-24)
Local intravitreal or intra-arterial chemotherapy has improved therapeutic success for the pediatric cancer retinoblastoma (RB), but toxicity remains a major caveat. RB initiates primarily with RB1 loss or, rarely, MYCN amplification, but the critical downstream networks are incompletely understood. We

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