SML0364
RAD51抑制剂B02
≥98% (HPLC), RAD51 recombinase inhibitor, powder
别名:
3-（苯甲基）-2-[（1E）-2-（3-吡啶基）乙烯基]-4（3H）-喹唑啉酮
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关于此项目
经验公式（希尔记法）:
C22H17N3O
化学文摘社编号:
分子量:
339.39
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
RAD51抑制剂B02, ≥98% (HPLC)
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to dark brown
solubility
DMSO: ≥5 mg/mL
storage temp.
2-8°C
SMILES string
O=C1N(CC2=CC=CC=C2)C(/C=C/C3=CN=CC=C3)=NC4=C1C=CC=C4
InChI
1S/C22H17N3O/c26-22-19-10-4-5-11-20(19)24-21(13-12-17-9-6-14-23-15-17)25(22)16-18-7-2-1-3-8-18/h1-15H,16H2/b13-12+
InChI key
GEKDQXSPTHHANP-OUKQBFOZSA-N
Application
RAD51 抑制剂B02已被用于：
- 测试其对猪卵母细胞极体排放（PBE）率的影响
- 用于猪胚胎的RAD51抑制
- 作为RAD51 抑制剂并用于测试其对诱导多能干细胞 (iPSC) 中靶向氨基酸替换 (TNS) 的影响
Biochem/physiol Actions
B02 (3-（苯甲基）-2-[（1E）-2-（3-吡啶基）乙烯基]-4（3H）-喹唑啉酮是一种吡啶基乙烯基喹唑啉酮化合物，可以穿透细胞。B02抑制人RAD51重组酶及之后核线的形成。它可以中止癌细胞中的同源重组（HR）修复活动。B02促进多发性骨髓瘤中的细胞凋亡，同时也是敏化多柔比星的关键。
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Ivana Murfuni et al.
PLoS genetics, 9(10), e1003910-e1003910 (2013-11-10)
In checkpoint-deficient cells, DNA double-strand breaks (DSBs) are produced during replication by the structure-specific endonuclease MUS81. The mechanism underlying MUS81-dependent cleavage, and the effect on chromosome integrity and viability of checkpoint deficient cells is only partly understood, especially in human
A small-molecule inhibitor of RAD51 reduces homologous recombination and sensitizes multiple myeloma cells to doxorubicin
Alagpulinsa DA, et al.
Frontiers in Oncology, 4, 289-289 (2014)
RAD51 maintains chromosome integrity and mitochondrial distribution during porcine oocyte maturation in vitro
Jin ZL and Kim NH
Journal of Reproduction and Development (2017)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SML0364-5MG | 04061837084393 |
| SML0364-25MG | 04061833025642 |