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SML0343

Methylstat

Name: Methylstat
Brand: SIGMA

≥98% (HPLC), Jumonji C domain-containing histone trimethyl demethylases (JHDMs) inhibitor, powder

别名:

(2E)-4-[Hydroxy[4-[[[4-[[[(1-naphthalenylamino)carbonyl]oxy]methyl]phenyl]methyl]amino]butyl]amino]-4-oxo-2-butenoic acid methyl ester

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关于此项目

经验公式（希尔记法）:

C₂₈H₃₁N₃O₆

化学文摘社编号:

1310877-95-2

分子量:

505.56

UNSPSC Code:

12352200

PubChem Substance ID:

329825348

NACRES:

NA.77

MDL number:

MFCD22572723

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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属性

产品名称

Methylstat, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: >5 mg/mL

storage temp.

2-8°C

SMILES string

O=C(NC1=CC=CC2=C1C=CC=C2)OCC3=CC=C(CNCCCCN(O)C(/C=C/C(OC)=O)=O)C=C3

InChI

1S/C28H31N3O6/c1-36-27(33)16-15-26(32)31(35)18-5-4-17-29-19-21-11-13-22(14-12-21)20-37-28(34)30-25-10-6-8-23-7-2-3-9-24(23)25/h2-3,6-16,29,35H,4-5,17-20H2,1H3,(H,30,34)/b16-15+

InChI key

MUJOCHRZXRZONW-FOCLMDBBSA-N

说明

Biochem/physiol Actions

Methylstat is an inhibitor of the Jumonji C domain-containing histone trimethyl demethylases (JHDMs).

Methylstat is an inhibitor of the Jumonji C domain-containing histone trimethyl demethylases (JHDMs). Methylstat inhibits the activity of JMJD2C (IC₅₀ = 4.3 μM), with similar potency against JMJD2E and JMJD3. The compound has poor activity against dimethyl demethylases, and does not inhibit class I or II HDACs. Methylsat blocks proliferation of the esophageal carcinoma cell line KYSE150 with an IC₅₀ value of 5.1 μM.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

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Lot/Batch Number

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Histone Methylation Participates in Gene Expression Control during the Early Development of the Pacific Oyster Crassostrea gigas.

Alexandre Fellous et al.

Genes, 10(9) (2019-09-13)

Histone methylation patterns are important epigenetic regulators of mammalian development, notably through stem cell identity maintenance by chromatin remodeling and transcriptional control of pluripotency genes. But, the implications of histone marks are poorly understood in distant groups outside vertebrates and

Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression.

Qingsong Hu et al.

Nature immunology, 20(7), 835-851 (2019-06-05)

How tumor cells genetically lose antigenicity and evade immune checkpoints remains largely elusive. We report that tissue-specific expression of the human long noncoding RNA LINK-A in mouse mammary glands initiates metastatic mammary gland tumors, which phenotypically resemble human triple-negative breast

LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition.