SML0340
Hydroxy-Dynasore
≥98% (HPLC)
别名:
3-Hydroxy-2-naphthalenecarboxylic acid 2-[(2,4,5-trihydroxyphenyl)methylene]hydrazide, 3-Hydroxy-N′-[(2,4,5-trihydroxyphenyl)methylidene]naphthalene-2-carbohydrazide
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所有图片(1)
About This Item
经验公式（希尔记法）:
C18H14N2O5
CAS号:
分子量:
338.31
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
质量水平
检测方案
≥98% (HPLC)
形式
powder
储存条件
protect from light
颜色
faintly yellow to dark yellow
溶解性
DMSO: >10 mg/mL
储存温度
2-8°C
SMILES字符串
Oc1cc(O)c(\C=N\NC(=O)c2cc3ccccc3cc2O)cc1O
InChI
1S/C18H14N2O5/c21-14-8-17(24)16(23)7-12(14)9-19-20-18(25)13-5-10-3-1-2-4-11(10)6-15(13)22/h1-9,21-24H,(H,20,25)/b19-9+
InChI key
UAXHPUSKEWEOAP-DJKKODMXSA-N
生化/生理作用
Hydroxy-Dynasore is a cell permeable and potent dynamin inhibitor that prevents uptake of recombinant botulinum neurotoxin A heavy chain binding domain (BoNT/A-Hc). Apparently, Hydroxy-Dynasore prevents dynamin-mediated fission of endocytic vesicles from the plasma membrane.
其他说明
Air sensitive.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Thao Nguyen et al.
Oncogene, 38(35), 6283-6300 (2019-07-18)
N-cadherin adhesion has been reported to enhance cancer and neuronal cell migration either by mediating actomyosin-based force transduction or initiating fibroblast growth factor receptor (FGFR)-dependent biochemical signalling. Here we show that FGFR1 reduces N-cadherin-mediated cell migration. Both proteins are co-stabilised
Keisuke Shirakura et al.
EMBO molecular medicine, 15(4), e16128-e16128 (2023-02-07)
Vascular endothelial protein tyrosine phosphatase (VE-PTP) influences endothelial barrier function by regulating the activation of tyrosine kinase receptor Tie2. We determined whether this action is linked to the development of atherosclerosis by examining the influence of arterial shear stress on
Alekhya Mazumdar et al.
International journal of molecular sciences, 21(15) (2020-08-06)
Tumor-secreted extracellular vesicles (EVs) have been identified as mediators of cancer-host intercellular communication and shown to support pre-metastatic niche formation by modulating stromal cells at future metastatic sites. While osteosarcoma, the most common primary malignant bone tumor in children and
Hui Yi Chew et al.
Cell, 180(5), 895-914 (2020-03-07)
A safe and controlled manipulation of endocytosis in vivo may have disruptive therapeutic potential. Here, we demonstrate that the anti-emetic/anti-psychotic prochlorperazine can be repurposed to reversibly inhibit the in vivo endocytosis of membrane proteins targeted by therapeutic monoclonal antibodies, as directly demonstrated
Yi-Zhi Wang et al.
Cell reports, 43(2), 113680-113680 (2024-01-19)
Extracellular vesicles (EVs) facilitate intercellular communication by transferring cargo between cells in a variety of tissues. However, how EVs achieve cell-type-specific intercellular communication is still largely unknown. We found that Notch1 and Notch2 proteins are expressed on the surface of
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