SML0340
Hydroxy-Dynasore
≥98% (HPLC), dynamin inhibitor, powder
别名:
3-Hydroxy-2-naphthalenecarboxylic acid 2-[(2,4,5-trihydroxyphenyl)methylene]hydrazide, 3-Hydroxy-N′-[(2,4,5-trihydroxyphenyl)methylidene]naphthalene-2-carbohydrazide
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C18H14N2O5
化学文摘社编号:
分子量:
338.31
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
Hydroxy-Dynasore, ≥98% (HPLC)
SMILES string
Oc1cc(O)c(\C=N\NC(=O)c2cc3ccccc3cc2O)cc1O
InChI
1S/C18H14N2O5/c21-14-8-17(24)16(23)7-12(14)9-19-20-18(25)13-5-10-3-1-2-4-11(10)6-15(13)22/h1-9,21-24H,(H,20,25)/b19-9+
InChI key
UAXHPUSKEWEOAP-DJKKODMXSA-N
assay
≥98% (HPLC)
form
powder
storage condition
protect from light
color
faintly yellow to dark yellow
solubility
DMSO: >10 mg/mL
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Hydroxy-Dynasore is a cell permeable and potent dynamin inhibitor.
Hydroxy-Dynasore is a cell permeable and potent dynamin inhibitor that prevents uptake of recombinant botulinum neurotoxin A heavy chain binding domain (BoNT/A-Hc). Apparently, Hydroxy-Dynasore prevents dynamin-mediated fission of endocytic vesicles from the plasma membrane.
Other Notes
Air sensitive.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Thao Nguyen et al.
Oncogene, 38(35), 6283-6300 (2019-07-18)
N-cadherin adhesion has been reported to enhance cancer and neuronal cell migration either by mediating actomyosin-based force transduction or initiating fibroblast growth factor receptor (FGFR)-dependent biochemical signalling. Here we show that FGFR1 reduces N-cadherin-mediated cell migration. Both proteins are co-stabilised
Hui Yi Chew et al.
Cell, 180(5), 895-914 (2020-03-07)
A safe and controlled manipulation of endocytosis in vivo may have disruptive therapeutic potential. Here, we demonstrate that the anti-emetic/anti-psychotic prochlorperazine can be repurposed to reversibly inhibit the in vivo endocytosis of membrane proteins targeted by therapeutic monoclonal antibodies, as directly demonstrated
Keisuke Shirakura et al.
EMBO molecular medicine, 15(4), e16128-e16128 (2023-02-07)
Vascular endothelial protein tyrosine phosphatase (VE-PTP) influences endothelial barrier function by regulating the activation of tyrosine kinase receptor Tie2. We determined whether this action is linked to the development of atherosclerosis by examining the influence of arterial shear stress on
Alekhya Mazumdar et al.
International journal of molecular sciences, 21(15) (2020-08-06)
Tumor-secreted extracellular vesicles (EVs) have been identified as mediators of cancer-host intercellular communication and shown to support pre-metastatic niche formation by modulating stromal cells at future metastatic sites. While osteosarcoma, the most common primary malignant bone tumor in children and
Yi-Zhi Wang et al.
Cell reports, 43(2), 113680-113680 (2024-01-19)
Extracellular vesicles (EVs) facilitate intercellular communication by transferring cargo between cells in a variety of tissues. However, how EVs achieve cell-type-specific intercellular communication is still largely unknown. We found that Notch1 and Notch2 proteins are expressed on the surface of
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持