SML0338
Lornoxicam
≥98% (HPLC)
别名:
6-Chloro-4-hydroxy-2-methyl-N-2-pyridinyl-2H-thieno[2,3-e]-1,2-thiazine-3-carboxamide 1,1-dioxide, Chlortenoxicam, Ro 13-9297, TS 110
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关于此项目
经验公式（希尔记法）:
C13H10ClN3O4S2
化学文摘社编号:
分子量:
371.82
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C13H10ClN3O4S2/c1-17-10(13(19)16-9-4-2-3-5-15-9)11(18)12-7(23(17,20)21)6-8(14)22-12/h2-6,18H,1H3,(H,15,16,19)
SMILES string
CN1C(C(=O)Nc2ccccn2)=C(O)c3sc(Cl)cc3S1(=O)=O
InChI key
WLHQHAUOOXYABV-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
faintly yellow to dark yellow
solubility
DMSO: >5 mg/mL (warmed)
storage temp.
−20°C
Quality Level
General description
Lornoxicam belongs to the oxicam class. It has anti-inflammatory and antipyretic properties. Lornoxicam prevents the synthesis of prostaglandin (PG) by inhibiting cyclo-oxygenase. It is used to relieve various types of symptoms associated with osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute sciatica and low back pain.
Application
Lornoxicam has been used as a drug in melanin binding study with cassette dosing and rapid equilibrium dialysis inserts.
Biochem/physiol Actions
Lornoxicam is an oxicam-class NSAID with strong analgesic properties.
Lornoxicam is an oxicam-class NSAID; cyclooxygenase inhibitor.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
M A Agapov et al.
Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology, (7)(7), 18-23 (2012-03-01)
Acute pancreatitis is a disease of variable severity. In which some patients experience mild, self-limited attacks while others manifest a severe, highly morbid, and frequently lethal attack. The exact mechanisms by which diverse etiological factors induce an attack are still
Ali Irfan Guzel et al.
Journal of experimental therapeutics & oncology, 9(4), 317-320 (2012-05-02)
We conducted a study to compare the analgesic effect of oral lornoxicam and oral paracetamol before endometrial sampling for benign conditions. This prospective, double-blind, randomized study was conducted on sixty women underwent endometrial sampling for benign indications, from November 2010
Zhiyue Zhang et al.
Drug delivery, 18(7), 536-544 (2011-08-05)
Owing to its rationale of targeting the drug to the site of action and minimizing systemic toxic effects of the drug, intra-articular drug delivery system has gained growing interests. In this study, emphasis was placed on intra-articular Lornoxicam-loaded PLGA microspheres
Hany A Mowafi et al.
World journal of surgery, 36(9), 2039-2044 (2012-05-16)
The aim of this prospective, randomized, double-blind study was to determine the more effective supplemental analgesic, paracetamol or lornoxicam, for postoperative pain relief after lower abdominal surgery. Sixty patients scheduled for lower abdominal surgery under general anesthesia were randomly allocated
Jianjun Zhang et al.
Pakistan journal of pharmaceutical sciences, 25(2), 371-375 (2012-03-31)
A rapid, isocratic stability indicating high performance liquid chromatographic method was developed and validated for the estimation of lornoxicam in its powder for injection. The analysis was performed on a Shimadzu VP-ODS (4. 6 mm x 15 cm, 5 µm)
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