所有图片(1)
About This Item
经验公式（希尔记法）:
C16H15NO7S
CAS号:
分子量:
365.36
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
推荐产品
质量水平
方案
≥97% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: >10 mg/mL
储存温度
−20°C
SMILES字符串
Cc1ccc(cc1)S(=O)(=O)OCC(=O)Nc2ccc(C(O)=O)c(O)c2
InChI
1S/C16H15NO7S/c1-10-2-5-12(6-3-10)25(22,23)24-9-15(19)17-11-4-7-13(16(20)21)14(18)8-11/h2-8,18H,9H2,1H3,(H,17,19)(H,20,21)
InChI key
HWNUSGNZBAISFM-UHFFFAOYSA-N
应用
S3I-201 已作为信号转导和转录激活剂 3 (STAT3) 的抑制剂，被用于：
- 确认 STAT3 磷酸化在肺上皮细胞中白细胞介素 (IL)-33 的产生 和在经分选的3类先天淋巴细胞 (ILC3s) 中 IL-22 mRNA 表达中的作用
- 研究在各种细胞系中由β-六氯环己烷 (β-HCH) 触发的STAT3细胞反应
- 检测响应血管紧张素 II (ang II) 所产生的STAT3对肾上皮细胞纤维化蛋白诱导的影响
生化/生理作用
S3I-201 是细胞可渗透的 Stat3 抑制剂。
S3I-201 是细胞可渗透的 Stat3 抑制剂，它结合 Stat3-SH2 结构域，阻止 Stat3 磷酸化/活化、二聚化，以及与 DNA 结合。
通过S3I-201抑制信号转导和转录激活因子 3 (STAT3) 的活性，可能是治疗高血压肾病的一种潜在治疗策略。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Kwang Bo Jung et al.
Nature communications, 9(1), 3039-3039 (2018-08-04)
Human pluripotent stem cell (hPSC)-derived intestinal organoids (hIOs) form 3D structures organized into crypt and villus domains, making them an excellent in vitro model system for studying human intestinal development and disease. However, hPSC-derived hIOs still require in vivo maturation
Safiye E Sarper et al.
Scientific reports, 8(1), 11208-11208 (2018-07-27)
Runx1 deficiency results in an anteriorly specific cleft palate at the boundary between the primary and secondary palates and in the first rugae area of the secondary palate in mice. However, the cellular and molecular pathogenesis underlying such regional specificity
Gaurav Kumar et al.
Radiology, 286(2), 524-536 (2017-09-08)
Purpose To (a) identify key expressed genes in the periablational rim after radiofrequency ablation (RFA) and their role in driving the stimulation of distant tumor growth and (b) use adjuvant drug therapies to block key identified mediator(s) to suppress off-target
Safiye E Sarper et al.
Scientific reports, 8(1), 10906-10906 (2018-07-22)
Rodent incisors grow permanently and the homeostasis of enamel production is maintained by a continuous supply of epithelial progenitors from putative stem cells in the cervical loop. We herein report that Runx1 regulates the Lgr5-expressing epithelial stem cells and their
Kwang Bo Jung et al.
Journal of clinical medicine, 8(7) (2019-07-07)
Human intestinal organoids (hIOs), which resemble the human intestine structurally and physiologically, have emerged as a new modality for the study of the molecular and cellular biology of the intestine in vitro. We recently developed an in vitro maturation technique
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