所有图片(1)
About This Item
经验公式（希尔记法）:
C16H15NO7S
CAS号:
分子量:
365.36
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
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质量水平
方案
≥97% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: >10 mg/mL
储存温度
−20°C
SMILES字符串
Cc1ccc(cc1)S(=O)(=O)OCC(=O)Nc2ccc(C(O)=O)c(O)c2
InChI
1S/C16H15NO7S/c1-10-2-5-12(6-3-10)25(22,23)24-9-15(19)17-11-4-7-13(16(20)21)14(18)8-11/h2-8,18H,9H2,1H3,(H,17,19)(H,20,21)
InChI key
HWNUSGNZBAISFM-UHFFFAOYSA-N
应用
S3I-201 已作为信号转导和转录激活剂 3 (STAT3) 的抑制剂，被用于：
- 确认 STAT3 磷酸化在肺上皮细胞中白细胞介素 (IL)-33 的产生 和在经分选的3类先天淋巴细胞 (ILC3s) 中 IL-22 mRNA 表达中的作用
- 研究在各种细胞系中由β-六氯环己烷 (β-HCH) 触发的STAT3细胞反应
- 检测响应血管紧张素 II (ang II) 所产生的STAT3对肾上皮细胞纤维化蛋白诱导的影响
生化/生理作用
S3I-201 是细胞可渗透的 Stat3 抑制剂，它结合 Stat3-SH2 结构域，阻止 Stat3 磷酸化/活化、二聚化，以及与 DNA 结合。
通过S3I-201抑制信号转导和转录激活因子 3 (STAT3) 的活性，可能是治疗高血压肾病的一种潜在治疗策略。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
Gaurav Kumar et al.
Radiology, 286(2), 524-536 (2017-09-08)
Purpose To (a) identify key expressed genes in the periablational rim after radiofrequency ablation (RFA) and their role in driving the stimulation of distant tumor growth and (b) use adjuvant drug therapies to block key identified mediator(s) to suppress off-target
Wei-Jan Wang et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 23(2), 503-513 (2016-07-21)
Cisplatin (CDDP) is frequently used in combination chemotherapy with paclitaxel for treating urothelial carcinoma of the urinary bladder (UCUB). CDDP cross-resistance has been suggested to develop with paclitaxel, thus hindering successful UCUB treatment. Therefore, elucidating the mechanisms underlying CDDP-induced anticancer
Sang-Hun Kim et al.
Molecular medicine reports, 16(6), 9224-9232 (2017-10-11)
Chlorogenic acid (CA) is a phenolic compound purified from coffee, fruits and their associated beverages, which possess various biological properties, such as antioxidant and anticarcinogenic activities. The present study evaluated the effects of CA on lipopolysaccharide (LPS)‑induced inflammation in RAW264.7
Safiye E Sarper et al.
Scientific reports, 8(1), 10906-10906 (2018-07-22)
Rodent incisors grow permanently and the homeostasis of enamel production is maintained by a continuous supply of epithelial progenitors from putative stem cells in the cervical loop. We herein report that Runx1 regulates the Lgr5-expressing epithelial stem cells and their
Kwang Bo Jung et al.
Journal of clinical medicine, 8(7) (2019-07-07)
Human intestinal organoids (hIOs), which resemble the human intestine structurally and physiologically, have emerged as a new modality for the study of the molecular and cellular biology of the intestine in vitro. We recently developed an in vitro maturation technique
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