所有图片(1)
别名:
5-(2-苯基-吡唑并[1,5-a]吡啶-3-基)-1H-吡唑并[3,4-c]哒嗪-3-基胺, 5-(2-苯基吡唑并[1,5-a]吡啶-3-基)-1H-吡唑并[3,4-c]吡啶并-3-胺, FR 180204
经验公式（希尔记法）:
C18H13N7
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质量水平
检测方案
≥98% (HPLC)
形式
powder
颜色
faintly yellow to dark yellow
溶解性
DMSO: ≥10 mg/mL
储存温度
2-8°C
SMILES字符串
Nc1n[nH]c2nnc(cc12)-c3c(nn4ccccc34)-c5ccccc5
InChI
1S/C18H13N7/c19-17-12-10-13(20-22-18(12)23-21-17)15-14-8-4-5-9-25(14)24-16(15)11-6-2-1-3-7-11/h1-10H,(H3,19,21,22,23)
InChI key
XVECMUKVOMUNLE-UHFFFAOYSA-N
应用
FR180204已被用作ERK抑制剂：
- 用于阻断细胞外信号调节激酶 (ERK) 以确认同源框B7 (HOXB7) 是否通过 AKT/丝裂原活化蛋白激酶 (MAPK) 信号传导调节迁移和增生过程
- 作为细胞外信号调节激酶 (ERK) 抑制剂用于研究信号通路抑制剂对分化和细胞牵引力的作用
- 用于确定这种信号蛋白对于间充质基质细胞(MSC)治疗功效是不是必需的。
生化/生理作用
FR180204是一种有效的细胞渗透性、ATP竞争性ERK1和ERK2抑制剂（促分裂原活化蛋白激酶（MAPK）/细胞外信号调节激酶（ERK）1/2）。
它可用于研究ERK的作用并用于药物开发。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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HOXB7 overexpression promotes cell proliferation and correlates with poor prognosis in gastric cancer patients by inducing expression of both AKT and MARKs
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商品
The mitogen-activated protein kinase (MAPK) family consists of stress-activated (SAPK) and MAPKs. Learn about their network of signal transduction cascades that mediate cellular responses to a diverse range of stimuli.
丝裂原活化蛋白激酶(MAPK)家族由应激激活(SAPK)和丝裂原活化(MAPK)的蛋白激酶组成。了解它们介导细胞多种刺激反应的信号转导级联网络。
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