所有图片(1)
About This Item
经验公式（希尔记法）:
CH3BNa2O2
CAS号:
分子量:
103.82
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
质量水平
检测方案
≥95% (NMR)
形式
powder
储存条件
desiccated
颜色
white to beige
溶解性
H2O: >15 mg/mL
储存温度
room temp
SMILES字符串
[Na+].[Na+].[BH3-]C([O-])=O
InChI
1S/CH4BO2.2Na/c2-1(3)4;;/h2H3,(H,3,4);;/q-1;2*+1/p-1
InChI key
SOFPSQNQOQPAAJ-UHFFFAOYSA-M
应用
CORM-A1可用于：
- 提供一氧化碳（CO）并测试其在酵母和原代星形胶质细胞培养基中氧化应激时的细胞保护作用
- 作为小鼠巨噬细胞 J774A.1 中的 CO 供体，以测试其对细胞内啡呔升高的影响β
- 测试其对视网膜神经节细胞自噬激活的影响
生化/生理作用
CORM-A1是一种水溶性一氧化碳（CO）释放分子，可用于研究CO对细胞系统的影响。一氧化碳（CO）是在血红素加氧酶降解血红素过程中产生的一种重要的气体信号调节因子。CORM-A1在哺乳动物细胞中具有抗氧化和抗炎作用。
它以 pH 值和随温度变化的方式介导 CO 的释放，进而缓解轻度血管舒张和低血压。在氧化应激过程中，CORM-A1 可在星形胶质细胞原代培养基中提供细胞保护。这种含硼的 CORM 可促进自噬作用。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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Myrna Constantin et al.
International journal of hypertension, 2012, 859235-859235 (2012-04-21)
Heme oxygenase (HO), a catabolic enzyme, provides the rate-limiting step in the oxidative breakdown of heme, to generate carbon monoxide (CO), iron, and biliverdin-IXα. Induction of the inducible form, HO-1, in tissues is generally regarded as a protective mechanism. Over
Cláudia Figueiredo-Pereira et al.
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Kapil K Upadhyay et al.
Toxicology and applied pharmacology, 360, 99-108 (2018-10-03)
Acute liver injury is frequently associated with oxidative stress. Here, we investigated the therapeutic potential of carbon monoxide releasing molecule A-1 (CORM A-1) in oxidative stress-mediated liver injury. Overnight-fasted mice were injected with acetaminophen (APAP; 300 mg/kg; intraperitoneally) and were sacrificed
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