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质量水平
方案
≥97% (HPLC)
表单
powder
旋光性
[α]/D -88 to -108°, c = 0.1 in water
储存条件
desiccated
颜色
white to beige
溶解性
H2O: ≥5 mg/mL
运输
wet ice
储存温度
−20°C
SMILES字符串
Cl.Nc1nccc2n(cnc12)[C@@H]3C=C(CO)[C@@H](O)[C@H]3O
InChI
1S/C12H14N4O3.ClH/c13-12-9-7(1-2-14-12)16(5-15-9)8-3-6(4-17)10(18)11(8)19;/h1-3,5,8,10-11,17-19H,4H2,(H2,13,14);1H/t8-,10-,11+;/m1./s1
InChI key
UNSKMHKAFPRFTI-FDKLLANESA-N
一般描述
3-去氮腺嘌呤A盐酸盐是腺苷的碳环类似物。 它具有抗转移特性。它可用于治疗埃博拉病毒疾病、胃癌、骨髓瘤和淋巴瘤。
应用
3-去氮腺嘌呤A盐酸盐已用于测试其对卵巢肿瘤进展的影响。它也已用作c33A2细胞中的S-腺苷高半胱氨酸水解酶（SAH）抑制剂。
3-去氮腺嘌呤A盐酸盐已用于考察自噬和凋亡在结直肠癌（CRC）细胞中的潜在作用。
生化/生理作用
3-Deazaneplanocin A（DZNep）是一种S-腺苷高半胱氨酸水解酶抑制剂和组蛋白甲基转移酶EZH2抑制剂。它通过抑制EZH2的表达来打开抑制的肿瘤抑制基因并诱导细胞凋亡。
特点和优势
这种化合物是基因调控研究的特色产品。点击此处发现更多特色基因调控产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
3-Deazaneplanocin A (DZNep), an inhibitor of S-adenosylmethionine-dependent methyltransferase, promotes erythroid differentiation
Fujiwara T, et al.
The Journal of Biological Chemistry, 289(12), 8121-8134 (2014)
Song-Hee Kim et al.
Biomolecules, 11(4) (2021-05-01)
EPHA3, a member of the EPH family, is overexpressed in various cancers. We demonstrated previously that EPHA3 is associated with radiation resistance in head and neck cancer via the PTEN/Akt/EMT pathway; the inhibition of EPHA3 significantly enhances the efficacy of
Downregulation of enhancer of Zeste Homolog 2 (EZH2) is essential for the induction of autophagy and apoptosis in colorectal cancer cells
Yao Y, et al.
Genes, 7(10), 83-83 (2016)
3-Deazaneplanocin A induces massively increased interferon-alpha production in Ebola virus-infected mice
Bray M, et al.
Antiviral research, 55(1), 151-159 (2002)
Epigenetic silencing of T H 1-type chemokines shapes tumour immunity and immunotherapy
Peng D, et al.
Nature, 527(7577), 249-249 (2015)
商品
We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.
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