所有图片(1)
About This Item
经验公式（希尔记法）:
C13H19N3O3
CAS号:
分子量:
265.31
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
质量水平
检测方案
≥97% (HPLC)
形式
powder
颜色
white to beige
溶解性
DMSO: 10 mg/mL (clear solution)
储存温度
−20°C
SMILES字符串
ONC(=O)CCCCCCC(=O)Nc1cccnc1
InChI
1S/C13H19N3O3/c17-12(15-11-6-5-9-14-10-11)7-3-1-2-4-8-13(18)16-19/h5-6,9-10,19H,1-4,7-8H2,(H,15,17)(H,16,18)
InChI key
PTJGLFIIZFVFJV-UHFFFAOYSA-N
生化/生理作用
Pyroxamide is an inhibitor of HDAC1 (IC50 = 100 nM). Pyroxamide induces apoptosis and cell cycle arrest in leukemia, bladder and prostate cancer cell lines.
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Yunwei Guo et al.
Acta pharmaceutica Sinica. B, 10(5), 825-836 (2020-06-13)
The transcription factor nuclear factor kappa B (NF-κB) is activated in hepatocytes in the pathogenesis of hepatic steatosis. However, the action mechanism of NF-κB remains to be established in the hepatic steatosis. In this study, the P50 subunit of NF-κB
Michael S Werner et al.
Nature communications, 14(1), 2095-2095 (2023-04-14)
Development can be altered to match phenotypes with the environment, and the genetic mechanisms that direct such alternative phenotypes are beginning to be elucidated. Yet, the rules that govern environmental sensitivity vs. invariant development, and potential epigenetic memory, remain unknown.
Angela K Carrillo et al.
Bioorganic & medicinal chemistry, 23(16), 5151-5155 (2015-02-01)
Two of the histone deacetylases, TbDAC1 and TbDAC3, have been reported to be essential genes in trypanosomes. Therefore, we tested the activity of a panel of human histone deacetylase inhibitors (HDACi) for their ability to block proliferation of Trypanosoma brucei
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