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SML0279

LG100268

Name: LG100268
Brand: SIGMA
Price: 584.64 CNY
Availability: InStock

≥98% (HPLC)

别名:

2- [1-（3,5,5,8,8-五甲基-5,6,7,8-四氢-2-萘基）环丙基]吡啶-5-羧酸, AGN 192620, ALRT 268., CD 3127, LG268, LGD 100268, LGD 1268

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25 G

¥584.64

100 G

¥2,325.78

500 G

¥8,599.99

1 KG

¥14,419.49

¥584.64

国内现货，预计发货时间2025年4月27日详情

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25 G

¥584.64

100 G

¥2,325.78

500 G

¥8,599.99

1 KG

¥14,419.49

About This Item

经验公式（希尔记法）:

C₂₄H₂₉NO₂

CAS号:

153559-76-3

分子量:

363.49

MDL编号:

MFCD01758574

UNSPSC代码:

12352200

PubChem化学物质编号:

329825287

NACRES:

NA.77

¥584.64

国内现货，预计发货时间2025年4月27日详情

获取大包装报价

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此商品	H7006	H3662	H8651
H3784 HEPES sodium salt	H7006 HEPES sodium salt	H3662 HEPES sodium salt solution	H8651 HEPES sodium salt
assay ≥99.0%	assay ≥99.0% (titration)	assay -	assay ≥99.0% (titration)
grade BioPerformance Certified	grade -	grade -	grade -
technique(s) activity assay: suitable, cell culture \| mammalian: suitable	technique(s) HPLC: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) -
Quality Level 400	Quality Level 400	Quality Level 200	Quality Level -
form powder	form powder	form solution	form powder
application(s) cell analysis diagnostic assay manufacturing general analytical life science and biopharma	application(s) diagnostic assay manufacturing general analytical ( ) life science and biopharma metabolomics	application(s) -	application(s) diagnostic assay manufacturing

生化/生理作用

LG100268 是类视黄醇 X 受体（RXR）激动剂。

LG100268（LG268）是一种有效的选择性类视色素和类视色素 X 受体（RXR）激动剂。Lg100268 与 α，β 和 γ RXR 受体结合，IC₅₀ = 3-4 nM，且对 RAR 视黄酸受体无活性。

特点和优势

该化合物在受体分类和信号转导手册中核受体（非甾体化合物）页面中进行了详细介绍。欲浏览其他手册页面，请点击这里。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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All-Trans Retinoic Acid Enhances Bacterial Flagellin-Stimulated Proinflammatory Responses in Human Monocyte THP-1 Cells by Upregulating CD14.

Thi Xoan Hoang et al.

BioMed research international, 2019, 8059312-8059312 (2020-01-18)

All-trans retinoic acid (ATRA), an active form of vitamin A, exerts immunomodulatory functions. In this study, we examined the immune potentiating effect of ATRA on bacterial flagellin-induced NF-κB activation and proinflammatory cytokine production in human monocytic cell line THP-1. ATRA

Rosiglitazone activation of PPARgamma suppresses fractalkine signaling.

Yihong Wan et al.

Journal of molecular endocrinology, 44(2), 135-142 (2009-10-24)

The nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma) is a key transcriptional regulator of both lipid metabolism and inflammation. The importance of PPARgamma is accentuated by the widespread use of synthetic PPARgamma agonists, thiazolidinediones (such as rosiglitazone), as drugs for

All-Trans Retinoic Acid Enhances Matrix Metalloproteinase 2 Expression and Secretion in Human Myeloid Leukemia THP-1 Cells.

Hien Thi Vu et al.

BioMed research international, 2018, 5971080-5971080 (2018-09-19)

All-trans retinoic acid (ATRA) is an effective drug for the induction therapy of acute promyelocytic leukemia. However, the treatment is associated with adverse events such as retinoic acid syndrome (RAS) in some patients, whose histologic characteristics included organ infiltration by

Development of a Magnetic Microbead Affinity Selection Screen (MagMASS) Using Mass Spectrometry for Ligands to the Retinoid X Receptor-α.

Michael D Rush et al.

Journal of the American Society for Mass Spectrometry, 28(3), 479-485 (2016-12-15)

To overcome limiting factors in mass spectrometry-based screening methods such as automation while still facilitating the screening of complex mixtures such as botanical extracts, magnetic microbead affinity selection screening (MagMASS) was developed. The screening process involves immobilization of a target

Regulation of retinoid-mediated signaling involved in skin homeostasis by RAR and RXR agonists/antagonists in mouse skin.

Janine Gericke et al.

PloS one, 8(4), e62643-e62643 (2013-05-03)

Endogenous retinoids like all-trans retinoic acid (ATRA) play important roles in skin homeostasis and skin-based immune responses. Moreover, retinoid signaling was found to be dysregulated in various skin diseases. The present study used topical application of selective agonists and antagonists

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LG100268

≥98% (HPLC)

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