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质量水平
检测方案
≥98% (HPLC)
形式
powder
储存条件
desiccated
颜色
white to light brown
溶解性
DMSO: >10 mg/mL
储存温度
2-8°C
SMILES字符串
Nc1ncnc2n([C@@H]3O[C@H](COCc4ccc(cc4)C#N)[C@@H](O)[C@H]3O)c(NCc5ccc(Cl)c(Cl)c5)nc12
InChI
1S/C25H23Cl2N7O4/c26-16-6-5-15(7-17(16)27)9-30-25-33-19-22(29)31-12-32-23(19)34(25)24-21(36)20(35)18(38-24)11-37-10-14-3-1-13(8-28)2-4-14/h1-7,12,18,20-21,24,35-36H,9-11H2,(H,30,33)(H2,29,31,32)/t18-,20-,21-,24-/m1/s1
InChI key
ZXGGCBQORXDVTE-UMCMBGNQSA-N
应用
VER-155008 可用作热休克蛋白 70（HSP70）的抑制剂：
- 研究其对人胚胎肾 293（HEK293T）细胞的作用
- 研究其对 Vero E6 细胞中病毒 mRNA 合成及蛋白表达的影响
- 研究其对大鼠癫痫发作的衰减作用
生化/生理作用
VER-155002是HSP70的小分子、ATP衍生物抑制剂（IC50 = 500 nM）。该化合物能够抑制多种结肠癌和乳腺癌细胞系的增殖，诱导BT474细胞的半胱天冬酶依赖性细胞凋亡，并下调HCT116细胞的Her2和Raf-1表达。
VER‐155008 可积极促进记忆恢复和轴突再生。此外，它还参与抑制非小细胞肺癌（NSCLC）的细胞周期进程和增殖。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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Virology, 553, 70-80 (2020-11-27)
Many viruses utilize molecular chaperone heat shock protein 90 (Hsp90) for protein folding and stabilization, however, the role of Hsp90 in herpesvirus lifecycle is obscure. Here, we provide evidence that Hsp90 participates in pseudorabies virus (PRV) replication. Viral growth kinetics
Wei Wen et al.
Experimental biology and medicine (Maywood, N.J.), 239(5), 638-645 (2014-03-29)
Lung cancer is the most common malignancy and exhibits significant morbidity and mortality worldwide. Among all lung cancer subtypes, non-small-cell lung cancer (NSCLC) accounts for the majority of all lung cancer cases. Although there have been intensive investigations on the
Miriam Schäfer et al.
FEBS letters, 591(21), 3567-3587 (2017-09-28)
The shedding of ectodomains is a crucial mechanism in many physiological and pathological events. A disintegrin and metalloprotease-17 (ADAM17) is a key sheddase involved in essential processes, such as development, regeneration, and immune defense. ADAM17 exists in two conformations which
Eunmi Lee et al.
Oncogene, 38(4), 469-482 (2018-09-01)
TNFα is a pleiotropic cytokine which fuels tumor cell growth, invasion, and metastasis in some malignancies, while in others it induces cytotoxic cell death. However, the molecular mechanism by which TNFα exerts its diverse effects on breast cancer subtypes remains
Ximeng Yang et al.
Frontiers in pharmacology, 9, 48-48 (2018-02-15)
Alzheimer's disease (AD) is a progressive neurodegenerative disorder resulting in structural brain changes and memory impairment. We hypothesized that reconstructing neural networks is essential for memory recovery in AD. Heat shock cognate 70 (HSC70), a member of the heat shock
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