所有图片(1)
别名:
3-(Dimethylamino)-N-[3-[(4-hydroxybenzoyl)amino]-4-methylphenyl]-benzamide
经验公式（希尔记法）:
C23H23N3O3
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检测方案
≥98% (HPLC)
形式
powder
颜色
white to beige
溶解性
DMSO: >5 mg/mL (warmed)
储存温度
2-8°C
SMILES字符串
CN(C)c1cccc(c1)C(=O)Nc2ccc(C)c(NC(=O)c3ccc(O)cc3)c2
InChI
1S/C23H23N3O3/c1-15-7-10-18(24-23(29)17-5-4-6-19(13-17)26(2)3)14-21(15)25-22(28)16-8-11-20(27)12-9-16/h4-14,27H,1-3H3,(H,24,29)(H,25,28)
InChI key
PYEFPDQFAZNXLI-UHFFFAOYSA-N
生化/生理作用
ZM-336372 is a potent inhibitor of the MAP kinase c-raf in in vitro assay systems (IC50 = 70 nM). In cell-based experiments, ZM-336372 induces c-raf activation through a novel feedback loop in which inhibition is counterbalanced by reactivation.
警示用语：
Warning
危险声明
危险分类
Aquatic Chronic 4 - Skin Sens. 1B
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
E M Weissinger et al.
British journal of cancer, 91(1), 186-192 (2004-06-10)
Activation of PKA by cAMP agonists, such as 8-Cl-cAMP activation, selectively causes rapid apoptosis in v-abl transformed fibroblasts by inhibiting the Raf-1 kinase. Here we investigated whether 8-Cl-cAMP is useful for the treatment of chronic myelogenous leukaemia (CML), which is
商品
The extracellular signal regulated kinase (ERK1 and ERK2) pathways are activated by mitogens and play an important role in controlling cell growth and differentiation.
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