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安全信息

SML0234

Sigma-Aldrich

Mitiglinide calcium

≥98% (HPLC)

别名:

(aS,3aR,7aS)-Octahydro-g-oxo-a-(phenylmethyl)-2H-isoindole-2-butanoic acid calcium salt, KAD 1229, Mitiglinide hemicalcium salt, S 21403, [2(S)-cis]-Octahydro-g-oxo-a-(phenylmethyl)-2H-isoindole-2-butanoic acid calclium salt

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50 μG
¥5,263.17

¥5,263.17

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50 μG
¥5,263.17

About This Item

经验公式（希尔记法）:
C19H24NO3·0.5Ca
CAS号:
145525-41-3
分子量:
334.44
MDL编号:
MFCD09955408
UNSPSC代码:
12352200
PubChem化学物质编号:
329825247
NACRES:
NA.77

¥5,263.17

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质量水平

100

方案

≥98% (HPLC)

表单

powder

旋光性

[α]/D +5 to +9° (c=1, MeOH)

储存条件

desiccated

颜色

white to beige

溶解性

DMSO: ≥10 mg/mL at warmed to 60 °C

储存温度

room temp

SMILES字符串

O=C(C[C@H](Cc1ccccc1)C(=O)O[Ca]OC(=O)[C@H](CC(=O)N2C[C@H]3CCCC[C@H]3C2)Cc4ccccc4)N5C[C@H]6CCCC[C@H]6C5

InChI

1S/2C19H25NO3.Ca/c2*21-18(20-12-15-8-4-5-9-16(15)13-20)11-17(19(22)23)10-14-6-2-1-3-7-14;/h2*1-3,6-7,15-17H,4-5,8-13H2,(H,22,23);/q;;+2/p-2/t2*15-,16+,17-;/m00./s1

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Supelco

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Carbopack™ Adsorbent

Supelco

10257

Carbopack™ Adsorbent

Carbopack™ Adsorbent matrix Carbopack™ C, 80-100 mesh, bottle of 10 g

10258

Carbopack™ Adsorbent

Carbopack™ Adsorbent matrix Carbopack™ B, 60-80 mesh, bottle of 10 g

20273

Carbopack™ Adsorbent

surface area

~24 m2/g

surface area

~10 m2/g

surface area

~10 m2/g

surface area

~100 m2/g

pore size

~0 cm3/g macroporosity, ~0 cm3/g microporosity, ~0 cm3/g mesoporosity, ~0 Å pore diameter

pore size

~0 cm3/g macroporosity, ~0 cm3/g mesoporosity, ~0 cm3/g microporosity, ~0 Å pore diameter

pore size

~0 cm3/g macroporosity, ~0 cm3/g mesoporosity, ~0 cm3/g microporosity, ~0 Å pore diameter

pore size

~0 cm3/g macroporosity, ~0 cm3/g mesoporosity, ~0 cm3/g microporosity, ~0 Å pore diameter

form

granular

form

granular

form

granular

form

granular

matrix

Carbopack™ Y

matrix

Carbopack™ C

matrix

Carbopack™ C

matrix

Carbopack™ B

packaging

bottle of 10 g

packaging

bottle of 10 g

packaging

bottle of 10 g

packaging

bottle of 10 g

生化/生理作用

Mitiglinide calcium is a highly selective KATP channel antagonist
Mitiglinide is a drug for the treatment of type 2 diabetes. It is a highly selective KATP channel antagonist Mitiglinide is a hypoglycemic agent that closes adenosine triphosphate (ATP)–sensitive potassium channels (KATP channel s) in the pancreatic β-islet cells.

特点和优势

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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    分析证书(COA)

    Lot/Batch Number
    0000149027
    0000149027
    0000032796
    0000032792
    0000018956

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    Hind Hadi et al.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 895-896, 131-136 (2012-04-17)
    A hollow fiber liquid phase microextraction (HF-LPME) in conjunction with reversed phase HPLC-UV method was developed for the extraction and determination of trace amounts of the antidiabetic drug, mitiglinide (MIT) in biological fluids. The drug was extracted from 10 mL
    Jin Ah Jung et al.
    Clinical drug investigation, 32(12), 799-804 (2012-10-27)
    In the treatment of diabetes mellitus, combined drugs with different mechanisms of action can be effective when adequate glycaemic control is difficult with monotherapy. A fixed-dose combination (FDC) tablet of mitiglinide and metformin has been developed as a second-line treatment
    L Jin et al.
    Arzneimittel-Forschung, 62(1), 40-45 (2012-02-15)
    A sensitive and specific method was developed and validated for the determination of mitiglinide in plasma using LC-MS/MS. The effect of gemfibrozil on the pharmacokinetics of orally administered mitiglinide in rats was investigated. The validated method in positive electrospray ionization
    H Konya et al.
    The Journal of international medical research, 37(6), 1904-1912 (2010-02-12)
    This study investigated the effects of mitiglinide in 16 patients with type 2 diabetes mellitus treated with 30 mg/day mitiglinide, divided into three doses given just before each meal, for approximately 12 months. A 450 kcal meal tolerance test was
    Haley M Phillippe et al.
    The Annals of pharmacotherapy, 44(10), 1615-1623 (2010-09-16)
    To review the pharmacology, pharmacokinetics, efficacy, and safety of mitiglinide, a rapid-acting insulin secretion-stimulating agent to determine its potential role in therapy for the treatment of type 2 diabetes mellitus. A MEDLINE search (1966-May 2010) was conducted for English-language, human
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