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质量水平
方案
≥98% (HPLC)
表单
powder
储存条件
desiccated
protect from light
颜色
white to beige
溶解性
H2O: ≥2 mg/mL
储存温度
2-8°C
SMILES字符串
O.OC(Cn1ccnc1)(P(O)(O)=O)P(O)(O)=O
InChI
1S/C5H10N2O7P2.H2O/c8-5(15(9,10)11,16(12,13)14)3-7-2-1-6-4-7;/h1-2,4,8H,3H2,(H2,9,10,11)(H2,12,13,14);1H2
InChI key
FUXFIVRTGHOMSO-UHFFFAOYSA-N
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应用
唑来膦酸一水合物用作：
- 作为抑制剂，抑制胶质母细胞瘤、乳腺癌肿瘤细胞 和前列腺癌细胞系LAPC4的增殖
- 与 D,L-丙交酯75：乙交酯25（PLGA）形成缀合物，分析其在股骨远端的骨形成功能
- 作为胶质母细胞瘤细胞中法尼基二磷酸合酶的抑制剂
生化/生理作用
唑来膦酸（唑来膦酸盐）是一种双膦酸盐骨吸收抑制剂，是基焦磷酸（FPP）合成酶的抑制剂，其会导致破骨细胞活性的下游抑制并减少骨吸收和转换。它已被用于治疗绝经后的骨质疏松症，佩吉特病、高钙血症，并结合癌症化疗以治疗已经扩散到骨骼的癌症引起的骨损伤。
唑来膦酸（唑来膦酸盐）是一种骨吸收抑制剂，是基焦磷酸合成酶的抑制剂
制备说明
本品在溶液中极其不稳定，复溶后应尽快使用。如果一定要保存溶液，最多可在2-8ºC下存放24小时。
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Xu Li et al.
International journal of pharmaceutics, 526(1-2), 69-76 (2017-04-30)
Bisphosphonates are used to treat bone diseases such as osteoporosis and cancer-induced bone pain and fractures. It is thought that modifying the pharmacokinetics and biodistribution profiles of bisphosphonates (i.e. rapid renal clearance and extensive bone absorption) will not only reduce
Low-dose zoledronate for the treatment of bone metastasis secondary to prostate cancer
Akoury E, et al.
Cancer Cell International, 19(1), 28-28 (2019)
Kiichi Yamamoto et al.
Parasitology international, 66(2), 89-99 (2016-12-07)
Recent evidence suggests that 1α,25-dihydroxyvitamin D3 (calcitriol, VD3), the active form of vitamin D (VD), can inhibit the proliferation of microorganisms. In the present study, we conducted in vitro experiments and utilized in vivo murine models to investigate the antimalarial
Xu Li et al.
ACS applied materials & interfaces, 11(7), 7311-7319 (2019-01-29)
Bisphosphonates are generally used to treat bone diseases, such as bone metastasis from cancer. There is evidence that, through the modification of the pharmacokinetics and biodistribution of bisphosphonates by formulating them into nanoparticles, they may be able to treat extraskeletal
Controlled delivery of zoledronate improved bone formation locally in vivo
Gou W, et al.
PLoS ONE, 9(3), e91317-e91317 (2014)
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