所有图片(1)
About This Item
经验公式（希尔记法）:
C20H25N3O2
CAS号:
分子量:
339.43
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
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质量水平
方案
≥95% (HPLC)
表单
oil
储存条件
desiccated
颜色
white to light brown
储存温度
2-8°C
SMILES字符串
O=C(CCCc1ccccc1)N2CCC[C@H]2C(=O)N3CCC[C@H]3C#N
InChI
1S/C20H25N3O2/c21-15-17-10-5-13-22(17)20(25)18-11-6-14-23(18)19(24)12-4-9-16-7-2-1-3-8-16/h1-3,7-8,17-18H,4-6,9-14H2/t17-,18-/m0/s1
InChI key
SPXFAUXQZWJGCJ-ROUUACIJSA-N
应用
KYP-2047可用于脯氨酰内肽酶介导的细胞信号转导研究。
生化/生理作用
KYP-2047可清除神经细胞氧化应激诱导的α-突触核蛋白聚集体。 α-突触核蛋白是帕金森病中路易小体的主要成分，可引起神经元细胞死亡和痴呆。
KYP-2047是一种非常有效的选择性脯氨酰寡肽酶（POP）抑制剂，也被称为脯氨酰内肽酶（PEP或PE）。 Ki = 0.023 nM（猪）。
KYP-2047是一种非常有效的选择性脯氨酰寡肽酶（POP）抑制剂，也被称为脯氨酰内肽酶（PEP或PE）。Ki = 0.023nM（猪）。在体外已发现KYP-2047对谷氨酸和氧气、葡萄糖剥夺具有神经保护作用。它还被用来抑制AcSDKP从其前体43-mer胸腺素β4（Tβ4）的形成。Ac-SDKP可参与造血干细胞分化，具有促血管生成作用和抗纤维化作用。
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Jianbin Zhang et al.
Life sciences, 270, 119131-119131 (2021-02-01)
Prolyl endopeptidase (PREP) is a serine endopeptidase widely distributed in the body, and accumulated evidence suggests that PREP participates in inflammation and oxidative stress. Here, we explored the effect of PREP gene disruption on hepatic inflammation and oxidative stress status
Yuki Maruyama et al.
Placenta, 53, 8-15 (2017-05-11)
Prolyl oligopeptidase (prolyl endopeptidase, Prep), a multifunctional protease hydrolyzing -Pro-X- peptide bonds, is highly expressed in the mouse placenta, but the function during development is not known. We explored the possibility of Prep's involvement in placental differentiation. We cultured trophoblast
Giovanna Casili et al.
Oncotarget, 12(17), 1663-1676 (2021-08-27)
Intestinal ischemia-reperfusion (II/R) develops when the blood flow to the intestines decreases, followed by the reestablishment of the blood supply to the ischemic tissue, resulting in intestinal mucosal barrier dysfunction, with consequent severe local and systemic inflammation. Acute lung injury
Reinis Svarcbahs et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 36(49), 12485-12497 (2016-12-09)
Decreased clearance of α-synuclein (aSyn) and aSyn protein misfolding and aggregation are seen as major factors in the pathogenesis of Parkinson's disease (PD) and other synucleinopathies that leads to disruption in neuronal function and eventually to cell death. Prolyl oligopeptidase
Giovanna Casili et al.
Biomedicines, 8(12) (2020-12-17)
(1) Background: Chronic venous insufficiency (CVI) is a common disorder related to functional and morphological abnormalities of the venous system. Inflammatory processes and angiogenesis alterations greatly concur to the onset of varicose vein. KYP-2047 is a selective inhibitor of prolyl
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