所有图片(1)
About This Item
经验公式（希尔记法）:
C18H13FN4O2
CAS号:
分子量:
336.32
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
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质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to tan
溶解性
DMSO: ≥10 mg/mL
储存温度
2-8°C
SMILES字符串
Fc1ccc(cc1)-c2nn(cc2C3NC(=O)NC3=O)-c4ccccc4
InChI
1S/C18H13FN4O2/c19-12-8-6-11(7-9-12)15-14(16-17(24)21-18(25)20-16)10-23(22-15)13-4-2-1-3-5-13/h1-10,16H,(H2,20,21,24,25)
InChI key
MPQWYPLPWGUMJE-UHFFFAOYSA-N
应用
DPH 可用于 c-Abl 酪氨酸激酶介导的细胞信号传导研究。
生化/生理作用
DPH 是一种强效细胞渗透性 c-Abl 激活剂。DPH 与肉豆蔻酰结合位点结合，导致 c-Abl 激酶活性的激活。该化合物可刺激 c-Abl 及其下游底物 Crk 的磷酸化。
DPH 结合并改变了 c-Abl 酪氨酸激酶肉豆蔻酰结合站点的构象。表现出刺激 c-Abl 活化的强效酶和细胞活性。
强效细胞渗透性 c-Abl 激活剂
特点和优势
这种化合物是激酶磷酸酶生物学研究的特色产品。点击此处发现更多特色激酶磷酸酶生物产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Jingsong Yang et al.
Chemistry & biology, 18(2), 177-186 (2011-02-23)
c-Abl kinase activity is regulated by a unique mechanism involving the formation of an autoinhibited conformation in which the N-terminal myristoyl group binds intramolecularly to the myristoyl binding site on the kinase domain and induces the bending of the αI
R M Wilson et al.
Nature communications, 7, 13723-13723 (2016-12-14)
Peatlands contain one-third of soil carbon (C), mostly buried in deep, saturated anoxic zones (catotelm). The response of catotelm C to climate forcing is uncertain, because prior experiments have focused on surface warming. We show that deep peat heating of
Suranjana Sen et al.
PloS one, 11(10), e0165300-e0165300 (2016-10-28)
The fatty acid composition of membrane glycerolipids is a major determinant of Staphylococcus aureus membrane biophysical properties that impacts key factors in cell physiology including susceptibility to membrane active antimicrobials, pathogenesis, and response to environmental stress. The fatty acids of
Yuki Okada et al.
ACS chemical neuroscience, 10(1), 563-572 (2018-10-23)
The abnormal aggregation of amyloid β-protein (Aβ) is considered central in the pathogenesis of Alzheimer's disease. We focused on membrane-mediated amyloidogenesis and found that amyloid fibrils formed on monosialoganglioside GM1 clusters were more toxic than those formed in aqueous solution.
Edoardo Mazzucchi et al.
Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society, 34(1), 92-99 (2016-08-05)
Hyperventilation (HV) is a commonly used electroencephalogram activation method. We analyzed EEG recordings in 22 normal subjects and 22 patients with focal epilepsy of unknown cause. We selected segments before (PRE), during (HYPER), and 5 minutes after (POST) HV. To
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